{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilson L"],"funding":["Brain Research UK","National Institute for Health Research (NIHR)","Rosetrees","Academy of Medical Sciences"],"pagination":["105298"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11400615"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107"],"pubmed_abstract":["<h4>Background</h4>Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury.<h4>Methods</h4>Exposure-response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study. Neurofilament protein-light (NFL), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) were assayed from serum sampled in the first 24 h; concentrations were divided into quintiles within GCS severity groups. Relationships with the Glasgow Outcome Scale-Extended were exam"],"journal":["EBioMedicine"],"pubmed_title":["Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury."],"pmcid":["PMC11400615"],"funding_grant_id":["ACF-2009-14-007","AMS-CSF4-Newcombe","NIHR 1","PG22-100010","NIHR302544"],"pubmed_authors":["Radoi A","Williams G","Rossi S","Golubovic J","Singh RD","Ziverte A","Rossaint R","Stanworth S","Posti JP","Galanaud D","Castano-Leon AM","Valeinis E","Perera N","Schafer N","Stamatakis E","Lightfoot R","Van Hecke W","Kornaropoulos E","Vamos Z","Smielewski P","Jiang JY","Foks K","Citerio G","Polinder S","Rhodes J","Skandsen T","Zeiler FA","Grossi F","George P","Ripatti S","Ylen P","Esser P","Brinck V","Levi L","Manara A","Glocker B","Gravesteijn B","Haitsma I","Legrand V","Tamas V","McMahon C","Dixit A","Tamosuitis T","Carbonara M","Parizel PM","Rocka S","Mattern J","Sakowitz O","Andreassen L","Amrein K","Winzeck S","Manley G","Vespa PM","Roise O","Rosenlund C","Depreitere B","Blaabjerg M","Majdan M","Gupta D","Audibert G","Menovsky T","Taylor MS","Chevallard G","Benali H","Murray L","van Essen TA","Ao BT","Helseth E","Nelson D","Vyvere TV","Tudora CM","Lecky F","Czeiter E","van Veen E","Whitehouse DP","Della Corte F","Voormolen D","Vulekovic P","Furmanov A","Curry N","Donoghue E","Takala R","Jones K","Dawes H","Đilvesi Đ","Czosnyka M","Mikolic A","Beauvais R","Younsi A","Richter S","Bellander BM","Lanyon L","Stevens R","Dreier J","Pomposo I","Bragge P","Gantner D","Sanchez-Porras R","Tolias C","Beer R","Johnson F","CENTER-TBI participants and investigators","Zoerle T","Wolf S","Marechal H","Vajkoczy P","Peul W","van der Jagt M","Andelic N","Rosenfeld J","Melegh B","Helbok R","Persona P","Maegele M","Vik A","Rambadagalla M","Gomez PA","Calappi E","Chieregato A","Puybasset L","Tibboel D","van Dijck JTJM","Dahyot-Fizelier C","Kowark A","Cooper JD","Newcombe VFJ","Rusnak M","Brooker J","Wilson L","Martino C","Palotie A","Ortolano F","Maas AIR","Kondziella D","Gratz J","Sewalt C","Volovici V","Zelinkova V","Duliere GL","Verheyden J","Ragauskas A","Richardson S","Gagliardo P","Laureys S","Vargiolu A","Boogert HD","Horton L","Sorinola A","Jacobs B","van Erp IA","Ezer E","Trapani T","Beretta L","Coburn MS","De Keyser V","Wang KKW","Theadom A","van Wijk RPJ","Ledoux D","Pisica D","Vega E","Thomas M","Azouvi P","Nieboer D","Sandor J","Pirinen M","Steyerberg EW","Stocchetti N","Cavallo S","Payen JF","Degos V","Koskinen LO","Calvi MR","Schou RF","Cabeleira M","Azzolini ML","Sundstrom N","Schwendenwein E","Stewart W","Van der Steen G","Thibaut A","Vallance S","Berardino M","Brazinova A","Coles J","Negru A","Frisvold S","Roe C","Unterberg A","Covic A","Lejeune A","Velt K","Correia M","Gao G","Bullinger M","Caccioppola A","Hutchinson PJ","Otesile O","Wiegers E","Schoechl H","Ghuysen A","Schmidt S","Giga L","Perlbarg V","Van Praag D","Schoonman G","Piippo-Karjalainen A","Haagsma JA","Belli A","Timmers M","Lozano GC","Kompanje E","Lefering R","Ercole A","von Steinbuchel N","Jankowski S","Huijben J","Bartels R","Helmrich IR","Buki A","Lagares A","Yang Z","Tenovuo O","Nyiradi J","Vilcinis R","Karan M","Lingsma H","Fabricius M","Rueckert D","van der Naalt J","Misset B","Nair N","Feigin VL","Rosenthal G","Dark P","Ples H","Oresic M","Clusmann H","Raj R","Kovacs N","Menon DK","Brorsson C","Anke A","Sahuquillo J","Mondello S","Gruen RL","Ackerlund C","Rosand J","Jarrett M","Barzo P","Kolias AG","Muraleedharan V","Cameron P","Antoni A","van Heugten C"],"additional_accession":[]},"is_claimable":false,"name":"Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injury.","description":"<h4>Background</h4>Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury.<h4>Methods</h4>Exposure-response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study. Neurofilament protein-light (NFL), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) were assayed from serum sampled in the first 24 h; concentrations were divided into quintiles within GCS severity groups. Relationships with the Glasgow Outcome Scale-Extended were exam","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-01T13:47:45.085Z","creation":"2025-04-04T00:42:37.745Z"},"accession":"S-EPMC11400615","cross_references":{"pubmed":["39191173"],"doi":["10.1016/j.ebiom.2024.105298"]}}