{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye J"],"funding":["the Open Fund Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital","The Foundation of Health Commission of Hubei Province","This work was supported by the Experimental Animal Resources Development and Utilization Project of Hubei Province of China","Innovative research program for graduates of Hubei University of Medicine","Innovative Research Program of Xiangyang No.1 People's Hospital","Innovative Research Program of Xiangyang No.1 People's Hospital"],"pagination":["567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11401276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Background
Umbilical cord blood (UCB) is a rich source of multifunctional stem cells characterized by low immunogenicity. Recent research in the fields of aging and regenerative medicine has revealed the potential of human umbilical cord blood-derived exosomes (UCB-Exos) in promoting wound healing, anti-aging, and regeneration. However, their role in neurodegenerative diseases, specifically Parkinson's disease (PD), remains unexplored. This study investigates the potential therapeutic effects and underlying mechanisms of UCB-Exos on PD.Methods
Large extracellular vesicles (LEv), Exos, and soluble fractions (SF) of human UCB plasma were extracted to investigate their effects on motor dysfunction of the MPTP-induced PD mouse model and identify the key components that improve "],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model."],"pmcid":["PMC11401276"],"funding_grant_id":["YC2024030","YC2022008","2024SCOF004","WJ2023M161","2020DFE025","YC2022003","XYY2023ZY04","YC2024017","YC2023006"],"pubmed_authors":["Dong J","Jiang Q","Sang M","Xie L","Gui J","Sun X","Feng S","Guo A","Qin B","Ye J"],"additional_accession":[]},"is_claimable":false,"name":"Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.","description":"Background
Umbilical cord blood (UCB) is a rich source of multifunctional stem cells characterized by low immunogenicity. Recent research in the fields of aging and regenerative medicine has revealed the potential of human umbilical cord blood-derived exosomes (UCB-Exos) in promoting wound healing, anti-aging, and regeneration. However, their role in neurodegenerative diseases, specifically Parkinson's disease (PD), remains unexplored. This study investigates the potential therapeutic effects and underlying mechanisms of UCB-Exos on PD.Methods
Large extracellular vesicles (LEv), Exos, and soluble fractions (SF) of human UCB plasma were extracted to investigate their effects on motor dysfunction of the MPTP-induced PD mouse model and identify the key components that improve ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-04T07:26:47.559Z","creation":"2025-04-05T18:44:25.389Z"},"accession":"S-EPMC11401276","cross_references":{"pubmed":["39277761"],"doi":["10.1186/s12951-024-02773-1"]}}