biostudies-literatureYe Jthe Open Fund Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe HospitalThe Foundation of Health Commission of Hubei ProvinceThis work was supported by the Experimental Animal Resources Development and Utilization Project of Hubei Province of ChinaInnovative research program for graduates of Hubei University of MedicineInnovative Research Program of Xiangyang No.1 People&apos;s HospitalInnovative Research Program of Xiangyang No.1 People's Hospital567https://www.ebi.ac.uk/biostudies/studies/S-EPMC11401276biostudies-literatureUnknown22(1)<h4>Background</h4>Umbilical cord blood (UCB) is a rich source of multifunctional stem cells characterized by low immunogenicity. Recent research in the fields of aging and regenerative medicine has revealed the potential of human umbilical cord blood-derived exosomes (UCB-Exos) in promoting wound healing, anti-aging, and regeneration. However, their role in neurodegenerative diseases, specifically Parkinson's disease (PD), remains unexplored. This study investigates the potential therapeutic effects and underlying mechanisms of UCB-Exos on PD.<h4>Methods</h4>Large extracellular vesicles (LEv), Exos, and soluble fractions (SF) of human UCB plasma were extracted to investigate their effects on motor dysfunction of the MPTP-induced PD mouse model and identify the key components that improve Journal of nanobiotechnologyUmbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.PMC11401276YC2024030YC20220082024SCOF004WJ2023M1612020DFE025YC2022003XYY2023ZY04YC2024017YC2023006Dong JJiang QSang MXie LGui JSun XFeng SGuo AQin BYe JfalseUmbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.<h4>Background</h4>Umbilical cord blood (UCB) is a rich source of multifunctional stem cells characterized by low immunogenicity. Recent research in the fields of aging and regenerative medicine has revealed the potential of human umbilical cord blood-derived exosomes (UCB-Exos) in promoting wound healing, anti-aging, and regeneration. However, their role in neurodegenerative diseases, specifically Parkinson's disease (PD), remains unexplored. This study investigates the potential therapeutic effects and underlying mechanisms of UCB-Exos on PD.<h4>Methods</h4>Large extracellular vesicles (LEv), Exos, and soluble fractions (SF) of human UCB plasma were extracted to investigate their effects on motor dysfunction of the MPTP-induced PD mouse model and identify the key components that improve 2024-01-01T00:00:00Z2024 Sep2026-06-04T07:26:47.559Z2025-04-05T18:44:25.389ZS-EPMC114012763927776110.1186/s12951-024-02773-1