biostudies-literatureUnknown39(4)Ding XNational Natural Science Foundation of ChinaInfluenza A virus (IAV) shows an extensive host range and rapid genomic variations, leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species transmission. This causes global pandemics and seasonal flu outbreaks, posing sustained threats worldwide. Thus, studying all IAVs' evolutionary patterns and underlying mechanisms is crucial for effective prevention and control. We developed FluTyping to identify IAV genotypes, to explore overall genetic diversity patterns and their restriction factors. FluTyping groups isolates based on genetic distance and phylogenetic relationships using whole genomes, enabling identification of each isolate's genotype. Three distinct genetic diversity patterns were observed: one genotype domination Virologica Sinica525-536https://www.ebi.ac.uk/biostudies/studies/S-EPMC11401451biostudies-literatureTransmission restriction and genomic evolution co-shape the genetic diversity patterns of influenza A virus.PMC11401451Ding XLiu JWu AJiang TfalseTransmission restriction and genomic evolution co-shape the genetic diversity patterns of influenza A virus.Influenza A virus (IAV) shows an extensive host range and rapid genomic variations, leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species transmission. This causes global pandemics and seasonal flu outbreaks, posing sustained threats worldwide. Thus, studying all IAVs' evolutionary patterns and underlying mechanisms is crucial for effective prevention and control. We developed FluTyping to identify IAV genotypes, to explore overall genetic diversity patterns and their restriction factors. FluTyping groups isolates based on genetic distance and phylogenetic relationships using whole genomes, enabling identification of each isolate's genotype. Three distinct genetic diversity patterns were observed: one genotype domination 2024-01-01T00:00:00Z2024 Aug2026-06-03T10:08:54.661Z2026-04-26T03:11:57.359ZS-EPMC114014513842325410.1016/j.virs.2024.02.005