{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nakajima K"],"funding":["Kanazawa University","Japan Society for the Promotion of Science"],"pagination":["814-824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11401792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(10)"],"pubmed_abstract":["<h4>Objective</h4>We aimed to establish a practical diagnostic index for Lewy body diseases (LBD), such as Parkinson's disease and dementia, with Lewy bodies in outpatient settings and criteria for exempting patients from late imaging.<h4>Methods</h4>We acquired early and late <sup>123</sup>I-metaiodobenzylguanidine (MIBG) images from 108 consecutive patients with suspected LBD and standardized heart-to-mediastinum (H/M) ratios for collimator conditions. Exclusions included young-onset Parkinson's disease (age < 50 years) and genetic transthyretin-type amyloidosis. We developed logistic models incorporating H/M ratios with or without age (n = 92). The sympathetic MIBG index for LBD (SMILe index), categorized LBD likelihood from 0 (lowest) to 1 (highest). Diagnostic accuracy was assessed as"],"journal":["Annals of nuclear medicine"],"pubmed_title":["Sympathetic <sup>123</sup>I-metaiodobenzylguanidine index for Lewy body disease: probability-based diagnosis and identifying patients exempt from late imaging."],"pmcid":["PMC11401792"],"funding_grant_id":["23K07203"],"pubmed_authors":["Nakajima K","Kinuya S","Wakabayashi H","Ono K","Matsumura T","Komatsu J"],"additional_accession":[]},"is_claimable":false,"name":"Sympathetic <sup>123</sup>I-metaiodobenzylguanidine index for Lewy body disease: probability-based diagnosis and identifying patients exempt from late imaging.","description":"<h4>Objective</h4>We aimed to establish a practical diagnostic index for Lewy body diseases (LBD), such as Parkinson's disease and dementia, with Lewy bodies in outpatient settings and criteria for exempting patients from late imaging.<h4>Methods</h4>We acquired early and late <sup>123</sup>I-metaiodobenzylguanidine (MIBG) images from 108 consecutive patients with suspected LBD and standardized heart-to-mediastinum (H/M) ratios for collimator conditions. Exclusions included young-onset Parkinson's disease (age < 50 years) and genetic transthyretin-type amyloidosis. We developed logistic models incorporating H/M ratios with or without age (n = 92). The sympathetic MIBG index for LBD (SMILe index), categorized LBD likelihood from 0 (lowest) to 1 (highest). Diagnostic accuracy was assessed as","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-18T13:07:01.988Z","creation":"2025-04-06T22:40:00.72Z"},"accession":"S-EPMC11401792","cross_references":{"pubmed":["38869809"],"doi":["10.1007/s12149-024-01950-4"]}}