biostudies-literatureUnknown36(9)El-Moataz Bellah Ahmed N<h4>Objective</h4>GAPO syndrome is usually diagnosed clinically owing to its characteristic features of growth retardation, alopecia, pseudoanodontia, and ophthalmic anomalies. Pseudoanodontia describes the failure of eruption of the two sets of teeth in these patients. Thus, the abnormal dental phenotype is the emergence of a set or part of a set of dentitions.<h4>Purpose</h4>This study reports the physical, oro-dental, and molecular findings of two new sibs with GAPO syndrome and provides a description of the dental phenotype of one of the patients reported before.<h4>Materials & methods</h4>The patients were subjected to full medical history taking and three generations-pedigree construction. They were phenotyped according to the elements of morphology: Standard terminology series. AfteThe Saudi dental journal1209-1214https://www.ebi.ac.uk/biostudies/studies/S-EPMC11402001biostudies-literatureAbnormal dental phenotypes in GAPO syndrome: A descriptive study with a new <i>ANTXR1</i> variant & insights on teeth eruption.PMC11402001El-Moataz Bellah Ahmed NMehrez MAbdel-Hamid MSMostafa MIfalseAbnormal dental phenotypes in GAPO syndrome: A descriptive study with a new <i>ANTXR1</i> variant & insights on teeth eruption.<h4>Objective</h4>GAPO syndrome is usually diagnosed clinically owing to its characteristic features of growth retardation, alopecia, pseudoanodontia, and ophthalmic anomalies. Pseudoanodontia describes the failure of eruption of the two sets of teeth in these patients. Thus, the abnormal dental phenotype is the emergence of a set or part of a set of dentitions.<h4>Purpose</h4>This study reports the physical, oro-dental, and molecular findings of two new sibs with GAPO syndrome and provides a description of the dental phenotype of one of the patients reported before.<h4>Materials & methods</h4>The patients were subjected to full medical history taking and three generations-pedigree construction. They were phenotyped according to the elements of morphology: Standard terminology series. Afte2024-01-01T00:00:00Z2024 Sep2026-06-02T23:19:03.634Z2025-04-04T01:18:06.639ZS-EPMC114020013928658410.1016/j.sdentj.2024.07.001