{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(21)"],"submitter":["Yang X"],"pubmed_abstract":["Varroa mites (Varroa destructor) are ectoparasites of honey bees (Apis mellifera) and cause serious damage to bee colonies. The mechanism of how varroa mites kill honey bees remains unclear. We have addressed the effects of the mites on bee immunity and the replication of a picorna-like virus, the deformed wing virus (DWV). The expression of genes encoding three antimicrobial peptides (abaecin, defensin, and hymenoptaecin) and four immunity-related enzymes (phenol oxidase, glucose dehydrogenase, glucose oxidase, and lysozyme) were used as markers to measure the difference in the immune response. We have demonstrated an example of an ectoparasite immunosuppressing its invertebrate host with the evidence that parasitization significantly suppressed expression of these immunity-related genes."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["7470-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1140434"],"repository":["biostudies-literature"],"pubmed_title":["Impact of an ectoparasite on the immunity and pathology of an invertebrate: evidence for host immunosuppression and viral amplification."],"pmcid":["PMC1140434"],"pubmed_authors":["Yang X","Cox-Foster DL"],"additional_accession":[]},"is_claimable":false,"name":"Impact of an ectoparasite on the immunity and pathology of an invertebrate: evidence for host immunosuppression and viral amplification.","description":"Varroa mites (Varroa destructor) are ectoparasites of honey bees (Apis mellifera) and cause serious damage to bee colonies. The mechanism of how varroa mites kill honey bees remains unclear. We have addressed the effects of the mites on bee immunity and the replication of a picorna-like virus, the deformed wing virus (DWV). The expression of genes encoding three antimicrobial peptides (abaecin, defensin, and hymenoptaecin) and four immunity-related enzymes (phenol oxidase, glucose dehydrogenase, glucose oxidase, and lysozyme) were used as markers to measure the difference in the immune response. We have demonstrated an example of an ectoparasite immunosuppressing its invertebrate host with the evidence that parasitization significantly suppressed expression of these immunity-related genes.","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 May","modification":"2025-04-20T02:03:36.106Z","creation":"2019-03-27T01:08:55Z"},"accession":"S-EPMC1140434","cross_references":{"pubmed":["15897457"],"doi":["10.1073/pnas.0501860102"]}}