{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen AM"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["120742"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11404707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["297"],"pubmed_abstract":["<h4>Purpose</h4>The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the apolipoprotein E4 (APOE4) allele. Their respective biomarkers, A/T/N, have been found to correlate with aspects of brain biochemistry, measured with magnetic resonance spectroscopy (MRS), indicating a potential for MRS to augment the A/T/N framework for staging and prediction of AD. Unfortunately, the relationships between MRS and A/T/N biomarkers are unclear, largely due to a lack of studies examining them in the context of the spatial and temporal model of T/N progression. Advanced MRS acquisition and post-processing approaches have enabled us "],"journal":["NeuroImage"],"pubmed_title":["Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly."],"pmcid":["PMC11404707"],"funding_grant_id":["R21 AG049348","R01 AG013616","R01 HL111724","R01 AG056031","R01 AG012101","R01 HL118624","R01 AG056531","R25 HL105444","R21 AG055002","P30 AG066512","R01 AG080672","P01 AG060882","R01 AG022374"],"pubmed_authors":["Gajdosik M","Ahmed W","Gaggi N","Ghuman M","Boutajangout A","Kirov II","Chen AM","Sheriff S","George A","Harvey P","Peralta R","Wisniewski T","Blessing EM","Rusinek H","de Leon MJ","Juchem C","Zheng H","Glodzik L","Osorio R","Debure L","Babb JS","Marsh K","Ahn S","Vedvyas A"],"additional_accession":[]},"is_claimable":false,"name":"Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly.","description":"<h4>Purpose</h4>The pathological hallmarks of Alzheimer's disease (AD), amyloid, tau, and associated neurodegeneration, are present in the cortical gray matter (GM) years before symptom onset, and at significantly greater levels in carriers of the apolipoprotein E4 (APOE4) allele. Their respective biomarkers, A/T/N, have been found to correlate with aspects of brain biochemistry, measured with magnetic resonance spectroscopy (MRS), indicating a potential for MRS to augment the A/T/N framework for staging and prediction of AD. Unfortunately, the relationships between MRS and A/T/N biomarkers are unclear, largely due to a lack of studies examining them in the context of the spatial and temporal model of T/N progression. Advanced MRS acquisition and post-processing approaches have enabled us ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-03T19:28:18.353Z","creation":"2026-04-30T03:11:58.167Z"},"accession":"S-EPMC11404707","cross_references":{"pubmed":["39029606"],"doi":["10.1016/j.neuroimage.2024.120742"]}}