{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu Q"],"funding":["Shanghai Office of Philosophy and Social Science"],"pagination":["837-844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11405473"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(5)"],"pubmed_abstract":["<h4>Purpose</h4>Postpartum depression (PPD) brings adverse and serious consequences to both new parents and newborns. Neuroticism affects PPD, which remains controversial for confounding factors and reverse causality in cross-sectional research. Therefore, mendelian randomization (MR) study has been adopted to investigate their causal relationship.<h4>Methods</h4>This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results' robustness, heterogeneity, and horizontal pleiotropy. The fixed effect model yielded the results of meta-analysis.<h4>Results</h4>In the IVW model, a meta-analysis of the MR study showed that neuroticism increased the risk of PPD (OR, 1.17; 95% CI, 1.11-1.25, p < 0.01). Reverse analysis showed that PPD could not genetically predict neuroticism. There was no significant heterogeneity or horizontal pleiotropy bias in this result.<h4>Conclusion</h4>Our study suggests neuroticism is the risk factor for PPD from a gene perspective and PPD is not the risk factor for neuroticism. This finding may provide new insights into prevention and intervention strategies for PPD according to early detection of neuroticism."],"journal":["Archives of women's mental health"],"pubmed_title":["Causal effects of neuroticism on postpartum depression: a bidirectional mendelian randomization study."],"pmcid":["PMC11405473"],"funding_grant_id":["2019BSH012"],"pubmed_authors":["Yue C","Li Y","Chen J","Ma J","Hu Q","Cong E","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Causal effects of neuroticism on postpartum depression: a bidirectional mendelian randomization study.","description":"<h4>Purpose</h4>Postpartum depression (PPD) brings adverse and serious consequences to both new parents and newborns. Neuroticism affects PPD, which remains controversial for confounding factors and reverse causality in cross-sectional research. Therefore, mendelian randomization (MR) study has been adopted to investigate their causal relationship.<h4>Methods</h4>This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results' robustness, heterogeneity, and horizontal pleiotropy. The fixed effect model yielded the results of meta-analysis.<h4>Results</h4>In the IVW model, a meta-analysis of the MR study showed that neuroticism increased the risk of PPD (OR, 1.17; 95% CI, 1.11-1.25, p < 0.01). Reverse analysis showed that PPD could not genetically predict neuroticism. There was no significant heterogeneity or horizontal pleiotropy bias in this result.<h4>Conclusion</h4>Our study suggests neuroticism is the risk factor for PPD from a gene perspective and PPD is not the risk factor for neuroticism. This finding may provide new insights into prevention and intervention strategies for PPD according to early detection of neuroticism.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:48:59.472Z","creation":"2025-04-04T02:48:59.472Z"},"accession":"S-EPMC11405473","cross_references":{"pubmed":["38634868"],"doi":["10.1007/s00737-024-01466-w"]}}