{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Wan YM"],"pubmed_abstract":["<h4>Background</h4>Hepatorenal syndrome (HRS) bears a very poor prognosis with unmet need for safe and effective therapies. This systematic review and meta-analysis aimed to re-assess safety and efficacy of terlipressin versus placebo or noradrenaline for HRS, based on previous randomized controlled trials (RCTs).<h4>Methods</h4>PubMed, EMBASE, MEDLINE (OvidSP) and Cochrane registers were searched for trials reporting HRS treatment by terlipressin or noradrenaline. Search terms included: \"hepatorenal syndrome\", \"terlipressin\", \"noradrenaline\", and corresponding synonyms. Comparisons between terlipressin, noradreanaline, placebo and albumin were included. Meta-analysis was conducted for treatment response (both HRS reversal and complete response), mortality and adverse events.<h4>Results</h"],"journal":["Frontiers in pharmacology"],"pagination":["1418826"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11408352"],"repository":["biostudies-literature"],"pubmed_title":["Terlipressin versus placebo or noradrenalin in the treatment of hepatorenal syndrome: a systematic review and meta-analysis."],"pmcid":["PMC11408352"],"pubmed_authors":["Huang SQ","Wu HM","Li YH","Yin HJ","Wan YM","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Terlipressin versus placebo or noradrenalin in the treatment of hepatorenal syndrome: a systematic review and meta-analysis.","description":"<h4>Background</h4>Hepatorenal syndrome (HRS) bears a very poor prognosis with unmet need for safe and effective therapies. This systematic review and meta-analysis aimed to re-assess safety and efficacy of terlipressin versus placebo or noradrenaline for HRS, based on previous randomized controlled trials (RCTs).<h4>Methods</h4>PubMed, EMBASE, MEDLINE (OvidSP) and Cochrane registers were searched for trials reporting HRS treatment by terlipressin or noradrenaline. Search terms included: \"hepatorenal syndrome\", \"terlipressin\", \"noradrenaline\", and corresponding synonyms. Comparisons between terlipressin, noradreanaline, placebo and albumin were included. Meta-analysis was conducted for treatment response (both HRS reversal and complete response), mortality and adverse events.<h4>Results</h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-03T21:59:26.248Z","creation":"2025-04-04T00:39:00.759Z"},"accession":"S-EPMC11408352","cross_references":{"pubmed":["39295934"],"doi":["10.3389/fphar.2024.1418826"]}}