biostudies-literatureUnknown14(1)Michel MUniversitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des SaarlandesPeople with type 2 diabetes mellitus (T2DM) show a high prevalence of steatotic liver disease (SLD), and especially metabolic dysfunction-associated steatotic liver disease (MASLD), with liver fibrosis. Their health-related quality of life (HRQL) is affected by multiple in part overlapping factors and aggravated by metabolic and liver-related comorbidities, including liver fibrosis stage. The aim of this study was to investigate the effect size of advanced fibrosis (AF) on the HRQL in people with T2DM. A total of 149 individuals with T2DM treated at a primary care provider within the German disease management program (DMP) were included in the final analysis. Vibration-controlled transient elastography (VCTE) was used to non-invasively detect steatosis and AF. The EQ-5D-3L questionnaire waScientific reports21650https://www.ebi.ac.uk/biostudies/studies/S-EPMC11408596biostudies-literatureImpairment of health-related quality of life among people with type 2 diabetes and advanced liver fibrosis.PMC11408596Doll MFunuyet-Salas JMichel MLabenz CSchattenberg JMAlqahtani SAGalle PRArmandi AfalseImpairment of health-related quality of life among people with type 2 diabetes and advanced liver fibrosis.People with type 2 diabetes mellitus (T2DM) show a high prevalence of steatotic liver disease (SLD), and especially metabolic dysfunction-associated steatotic liver disease (MASLD), with liver fibrosis. Their health-related quality of life (HRQL) is affected by multiple in part overlapping factors and aggravated by metabolic and liver-related comorbidities, including liver fibrosis stage. The aim of this study was to investigate the effect size of advanced fibrosis (AF) on the HRQL in people with T2DM. A total of 149 individuals with T2DM treated at a primary care provider within the German disease management program (DMP) were included in the final analysis. Vibration-controlled transient elastography (VCTE) was used to non-invasively detect steatosis and AF. The EQ-5D-3L questionnaire wa2024-01-01T00:00:00Z2024 Sep2025-04-20T00:39:50.428Z2025-04-20T00:39:50.428ZS-EPMC114085963928941010.1038/s41598-024-72105-8