biostudies-literatureWu YCTaichung Veterans General HospitalNational Science and Technology Council34https://www.ebi.ac.uk/biostudies/studies/S-EPMC11409593biostudies-literatureUnknown12(1)<h4>Background</h4>Sepsis is the leading cause of death worldwide, and a number of biomarkers have been developed for early mortality risk stratification. Red blood cell distribution width (RDW) is a routinely available hematological data and has been found to be associated with mortality in a number of diseases; therefore, we aim to address the association between RDW and mortality in critically ill patients with sepsis.<h4>Methods</h4>We analyzed data of critically ill adult patients with sepsis on the TriNetX platform, excluding those with hematologic malignancies, thalassemia, and iron deficiency anemia. Propensity score-matching (PSM) (1:1) was used to mitigate confounding effects, and hazard ratio (HR) with 95% confidence (CI) was calculated to determine the association between RDW aJournal of intensive careAssociation between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study.PMC11409593NSTC 112-2314-B-075A-001 -MY2113G2121124401C1134401C1134402B112G213Wu YCChen HHChao WCfalseAssociation between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study.<h4>Background</h4>Sepsis is the leading cause of death worldwide, and a number of biomarkers have been developed for early mortality risk stratification. Red blood cell distribution width (RDW) is a routinely available hematological data and has been found to be associated with mortality in a number of diseases; therefore, we aim to address the association between RDW and mortality in critically ill patients with sepsis.<h4>Methods</h4>We analyzed data of critically ill adult patients with sepsis on the TriNetX platform, excluding those with hematologic malignancies, thalassemia, and iron deficiency anemia. Propensity score-matching (PSM) (1:1) was used to mitigate confounding effects, and hazard ratio (HR) with 95% confidence (CI) was calculated to determine the association between RDW a2024-01-01T00:00:00Z2024 Sep2025-04-04T02:20:27.048Z2025-04-04T02:20:27.048ZS-EPMC114095933929476010.1186/s40560-024-00747-x