{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang G"],"funding":["National Natural Science Foundation of China"],"pagination":["319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11409682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Tumor metastasis is a continuous and dynamic process and is a major cause of tumor-related death in triple-negative breast cancer. However, this biological process remains largely unknown in triple-negative breast cancer. The emergence of single-cell sequencing enables a deeper understanding of the tumor microenvironment and provides a new strategy for discovering the potential mechanism of tumor metastasis. Herein, we integrated the single-cell expression profiling of primary and metastatic triple-negative breast cancer by Seurat package. Nine tumor cell subgroups were identified. Enrichment analysis suggested tumor subgroups (C0, C4) were associated with tumor metastasis with poor prognosis in TNBC. Weighted gene co-expression network was constructed and identified NENF was a metastasis-"],"journal":["Cancer cell international"],"pubmed_title":["Identification of the tumor metastasis-related tumor subgroups overexpressed NENF in triple-negative breast cancer by single-cell transcriptomics."],"pmcid":["PMC11409682"],"funding_grant_id":["82303857","82304025","82172835"],"pubmed_authors":["Li Y","Liu Z","Shi C","Chen Z","He X","Tian Y","Wang G","He L","Wang X","Wang Y","Song W","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Identification of the tumor metastasis-related tumor subgroups overexpressed NENF in triple-negative breast cancer by single-cell transcriptomics.","description":"Tumor metastasis is a continuous and dynamic process and is a major cause of tumor-related death in triple-negative breast cancer. However, this biological process remains largely unknown in triple-negative breast cancer. The emergence of single-cell sequencing enables a deeper understanding of the tumor microenvironment and provides a new strategy for discovering the potential mechanism of tumor metastasis. Herein, we integrated the single-cell expression profiling of primary and metastatic triple-negative breast cancer by Seurat package. Nine tumor cell subgroups were identified. Enrichment analysis suggested tumor subgroups (C0, C4) were associated with tumor metastasis with poor prognosis in TNBC. Weighted gene co-expression network was constructed and identified NENF was a metastasis-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-02T22:15:27.24Z","creation":"2025-04-06T12:51:05.283Z"},"accession":"S-EPMC11409682","cross_references":{"pubmed":["39294690"],"doi":["10.1186/s12935-024-03505-z"]}}