biostudies-literatureDong Lthe Key R&amp;D Project of Shandong Provincethe Natural Fund Program of Shandong Provincethe National Natural Science Foundation of Shandong ProvinceYantai Science and Technology Program of Yantai CityChina Postdoctoral Science Foundationthe Key R&D Project of Shandong Provincethe Taishan Scholar Project1165https://www.ebi.ac.uk/biostudies/studies/S-EPMC11411997biostudies-literatureUnknown24(1)<h4>Background</h4>Cancer-associated fibroblasts (CAFs), as key cell populations in the tumor microenvironment (TME), play a crucial role in tumor regulation. Previous studies on a prognostic signature of 8 CAF-related genes in head and neck squamous cell carcinoma (HNSCC) revealed that Secreted frizzled-related protein 1 (SFRP1) is one of the hub genes closely related to CAFs. SFRP1 is deficiently expressed in numerous types of cancer and is classified as a tumor suppressor gene. However, the role of SFRP1 in TME regulation in HNSCC remains unclear. This study aimed to explore the role of SFRP1 in the proliferation and migration of HNSCC cells by mediating CAFs and their regulatory mechanisms.<h4>Methods</h4>The expression differences, prognosis, and immune infiltration of SFRP1 in HNSCC BMC cancerSFRP1 mediates cancer-associated fibroblasts to suppress cancer cell proliferation and migration in head and neck squamous cell carcinoma.PMC11411997No. 2022YD0072023M741861No. ZR2023QH358No. ZR202211250135No.2022CXPT023No.ts20190991Li YSun CDong LSong XfalseSFRP1 mediates cancer-associated fibroblasts to suppress cancer cell proliferation and migration in head and neck squamous cell carcinoma.<h4>Background</h4>Cancer-associated fibroblasts (CAFs), as key cell populations in the tumor microenvironment (TME), play a crucial role in tumor regulation. Previous studies on a prognostic signature of 8 CAF-related genes in head and neck squamous cell carcinoma (HNSCC) revealed that Secreted frizzled-related protein 1 (SFRP1) is one of the hub genes closely related to CAFs. SFRP1 is deficiently expressed in numerous types of cancer and is classified as a tumor suppressor gene. However, the role of SFRP1 in TME regulation in HNSCC remains unclear. This study aimed to explore the role of SFRP1 in the proliferation and migration of HNSCC cells by mediating CAFs and their regulatory mechanisms.<h4>Methods</h4>The expression differences, prognosis, and immune infiltration of SFRP1 in HNSCC 2024-01-01T00:00:00Z2024 Sep2025-04-04T01:15:06.806Z2025-04-04T01:15:06.806ZS-EPMC114119973930037310.1186/s12885-024-12907-1