biostudies-literatureUnknown15Clement G<h4>Introduction</h4>Bed rest can be used as a ground-based analog of the body unloading associated with spaceflight. In this study, we determined how strict head-down tilt bed rest affects subjects' performance of functional tests (sit-to-stand, tandem walk, walk-and-turn, dynamic posturography) that challenge astronauts' balance control systems immediately after they return from space.<h4>Methods</h4>Forty-seven participants were assessed before and a few hours after 30 days of 6° head down tilt bed rest at the DLR:envihab facility. During this bed rest study, called SANS-CM, the participants were divided into 4 groups that either a) were positioned in head-down tilt continuously throughout the 30 days; b) sat upright for 6 h a day; c) were exposed to lower body negative pressure (LBNP) Frontiers in physiology1442239https://www.ebi.ac.uk/biostudies/studies/S-EPMC11412840biostudies-literatureEffects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bed rest.PMC11412840Clement GMacaulay TRMoudy SCWood SJMulder EfalseEffects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bed rest.<h4>Introduction</h4>Bed rest can be used as a ground-based analog of the body unloading associated with spaceflight. In this study, we determined how strict head-down tilt bed rest affects subjects' performance of functional tests (sit-to-stand, tandem walk, walk-and-turn, dynamic posturography) that challenge astronauts' balance control systems immediately after they return from space.<h4>Methods</h4>Forty-seven participants were assessed before and a few hours after 30 days of 6° head down tilt bed rest at the DLR:envihab facility. During this bed rest study, called SANS-CM, the participants were divided into 4 groups that either a) were positioned in head-down tilt continuously throughout the 30 days; b) sat upright for 6 h a day; c) were exposed to lower body negative pressure (LBNP) 2024-01-01T00:00:00Z20242026-06-04T03:08:46.933Z2025-04-06T03:48:04.159ZS-EPMC114128403930897810.3389/fphys.2024.1442239