{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Guarnieri A"],"pubmed_abstract":["<h4>Introduction</h4>Managing burn injuries is a challenge in healthcare. Due to the alarming increase in antibiotic resistance, new prophylactic and therapeutic strategies are being sought. This study aimed to evaluate the potential of live Lactic Acid Bacteria for managing burn infections, using <i>Galleria mellonella larvae</i> as an alternative preclinical animal model and comparing the outcomes with a common antibiotic.<h4>Methods</h4>The antimicrobial activity of LAB isolated from human breast milk was assessed <i>in vitro</i> against <i>Pseudomonas aeruginosa</i> ATCC 27853. Additionally, the immunomodulatory effects of LAB were evaluated <i>in vivo</i> using the <i>G. mellonella</i> burn wound infection model.<h4>Results and discussion</h4><i>In vitro</i> results demonstrated the a"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1428525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11412949"],"repository":["biostudies-literature"],"pubmed_title":["Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on the <i>Galleria mellonella</i> burn wound model."],"pmcid":["PMC11412949"],"pubmed_authors":["Brancazio N","Petronio Petronio G","Falcone M","Cutuli MA","Pietrangelo L","Davinelli S","Scapagnini G","Venditti N","Guarnieri A","Nicolosi D","Di Marco R","Magnifico I","Salvatore G","Vergalito F","Scarsella F"],"additional_accession":[]},"is_claimable":false,"name":"Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on the <i>Galleria mellonella</i> burn wound model.","description":"<h4>Introduction</h4>Managing burn injuries is a challenge in healthcare. Due to the alarming increase in antibiotic resistance, new prophylactic and therapeutic strategies are being sought. This study aimed to evaluate the potential of live Lactic Acid Bacteria for managing burn infections, using <i>Galleria mellonella larvae</i> as an alternative preclinical animal model and comparing the outcomes with a common antibiotic.<h4>Methods</h4>The antimicrobial activity of LAB isolated from human breast milk was assessed <i>in vitro</i> against <i>Pseudomonas aeruginosa</i> ATCC 27853. Additionally, the immunomodulatory effects of LAB were evaluated <i>in vivo</i> using the <i>G. mellonella</i> burn wound infection model.<h4>Results and discussion</h4><i>In vitro</i> results demonstrated the a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T23:44:02.381Z","creation":"2025-04-04T23:44:02.381Z"},"accession":"S-EPMC11412949","cross_references":{"pubmed":["39310784"],"doi":["10.3389/fcimb.2024.1428525"]}}