{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lorenz J"],"pubmed_abstract":["To locate and fertilize the egg, sperm probe the varying microenvironment prevailing at different stages during their journey across the female genital tract. To this end, they are equipped with a unique repertoire of mostly sperm-specific proteins. In particular, the flagellar Ca<sup>2+</sup> channel CatSper has come into focus as a polymodal sensor used by human sperm to register ligands released into the female genital tract. Here, we provide the first comprehensive study on the pharmacology of the sperm-specific human Slo3 channel, shedding light on its modulation by reproductive fluids and their constituents. We show that seminal fluid and contained prostaglandins and Zn<sup>2+</sup> do not affect the channel, whereas human Slo3 is inhibited in a non-genomic fashion by diverse steroid"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1275116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11413451"],"repository":["biostudies-literature"],"pubmed_title":["The sperm-specific K<sup>+</sup> channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids."],"pmcid":["PMC11413451"],"pubmed_authors":["Mittermair T","Behre HM","Lorenz J","Eisenhardt C","Kulle AE","Nordhoff V","Boenigk W","Fobker M","Brenker C","Holterhus PM","Strunker T"],"additional_accession":[]},"is_claimable":false,"name":"The sperm-specific K<sup>+</sup> channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids.","description":"To locate and fertilize the egg, sperm probe the varying microenvironment prevailing at different stages during their journey across the female genital tract. To this end, they are equipped with a unique repertoire of mostly sperm-specific proteins. In particular, the flagellar Ca<sup>2+</sup> channel CatSper has come into focus as a polymodal sensor used by human sperm to register ligands released into the female genital tract. Here, we provide the first comprehensive study on the pharmacology of the sperm-specific human Slo3 channel, shedding light on its modulation by reproductive fluids and their constituents. We show that seminal fluid and contained prostaglandins and Zn<sup>2+</sup> do not affect the channel, whereas human Slo3 is inhibited in a non-genomic fashion by diverse steroid","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-30T00:05:09.305Z","creation":"2025-04-06T13:21:44.708Z"},"accession":"S-EPMC11413451","cross_references":{"pubmed":["39310227"],"doi":["10.3389/fcell.2024.1275116"]}}