{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Evans KT"],"funding":["Feodor-Lynen fellowship from the Alexander-von-Humboldt Stiftung","Canadian Institutes of Health Research Postdoctoral Fellowship","NIBIB NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NINDS NIH HHS","NCI NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health","Division of Intramural Research, National Institute of Allergy and Infectious Diseases","NIGMS NIH HHS"],"pagination":["1848-1859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11414741"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior work has shown that brain cancers and metastases are densely infiltrated with anti-inflammatory, protumourigenic tumour-associated macrophages, but the role of brain-resident microglia remains controversial because they are challenging to discriminate from other tumour-associated macrophages. Using single-cell RNA sequencing, genetic and humanized mouse models, we specifically identify microglia and find that they play a distinct pro-inflammatory and tumour-suppressive role in BCBM. Animals lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses, showing that microglia are critical to promote anti-tumour immunity to suppress BCBM. We find tha"],"journal":["Nature cell biology"],"pubmed_title":["Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis."],"pmcid":["PMC11414741"],"funding_grant_id":["U54-CA-217378","T32NS121727-01","F31 CA281331","NIHT32EB009418","T32 NS082174","K99 CA267160","T32NS082174","R01 CA237376","R01NS120060","1K99CA267160-01","T32 NS121727","T32AI 0602573","F31CA281331","R01CA237376-01A1","T32 GM136624","T32 GM008620","U54 CA217378","R01 NS120060","P30 CA062203","T32 EB009418","T32GM136624"],"pubmed_authors":["Orujyan D","McMullen TP","Blurton-Jones M","Pridans C","Villalta SA","Evans KT","Insua-Rodriguez J","Lev T","Blake K","Green KN","Coburn MA","Longworth A","Nguyen QH","Lawson DA","Edwards RA","Ma D","Oganyan AK","Hernandez GA"],"additional_accession":[]},"is_claimable":false,"name":"Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis.","description":"Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior work has shown that brain cancers and metastases are densely infiltrated with anti-inflammatory, protumourigenic tumour-associated macrophages, but the role of brain-resident microglia remains controversial because they are challenging to discriminate from other tumour-associated macrophages. Using single-cell RNA sequencing, genetic and humanized mouse models, we specifically identify microglia and find that they play a distinct pro-inflammatory and tumour-suppressive role in BCBM. Animals lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses, showing that microglia are critical to promote anti-tumour immunity to suppress BCBM. We find tha","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-01T10:05:23.356Z","creation":"2025-04-04T08:22:18.623Z"},"accession":"S-EPMC11414741","cross_references":{"pubmed":["37957324"],"doi":["10.1038/s41556-023-01273-y"]}}