{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jana S"],"funding":["Swedish Cancer Research Foundation","Ministry of Human Resource Development","LUA/ALF and the VAJRA Faculty Scheme","Barncancerfonden","Department of Science and Technology, Ministry of Science and Technology, India","Swedish Research Council","IngaBritt och Arne Lundbergs Forskningsstiftelse","Department of Biotechnology, Ministry of Science and Technology, India"],"pagination":["RP88256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11415074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, <i>PITAR</i> (<i>p</i>53 <i>I</i>nactivating <i>T</i>RIM28 <i>A</i>ssociated <i>R</i>NA), as an inhibitor of p53. <i>PITAR</i> is an oncogenic Cancer/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that <i>TRIM28</i> mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of <i>PITAR. PITAR</i> interaction with <i>TRIM28</i> RNA stabilized <i>TRIM28</i> mRNA, which resulted in increased TRIM28 protein levels and reduced p53 steady-state levels due to enhanced p53 ubiquitination. DNA damage activated <i>PITAR</i>, in addition to p53, in a p53-independent manner, thus creating an incoherent f"],"journal":["eLife"],"pubmed_title":["<i>PITAR</i>, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing <i>TRIM28</i> mRNA."],"pmcid":["PMC11415074"],"funding_grant_id":["NPDF","LU2020-0017","(VJR/2021/000008","2022–01262","STARS","211416Pj01H","2022-01262","PR2021-0026"],"pubmed_authors":["Gupta B","Mahale S","Mondal M","Jha N","Somasundaram K","Prasasvi KR","Santosh V","Kanduri C","Chowdhury A","Jana S","Kandasami L"],"additional_accession":[]},"is_claimable":false,"name":"<i>PITAR</i>, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing <i>TRIM28</i> mRNA.","description":"In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, <i>PITAR</i> (<i>p</i>53 <i>I</i>nactivating <i>T</i>RIM28 <i>A</i>ssociated <i>R</i>NA), as an inhibitor of p53. <i>PITAR</i> is an oncogenic Cancer/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that <i>TRIM28</i> mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of <i>PITAR. PITAR</i> interaction with <i>TRIM28</i> RNA stabilized <i>TRIM28</i> mRNA, which resulted in increased TRIM28 protein levels and reduced p53 steady-state levels due to enhanced p53 ubiquitination. DNA damage activated <i>PITAR</i>, in addition to p53, in a p53-independent manner, thus creating an incoherent f","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-01T10:04:12.131Z","creation":"2025-04-04T08:21:56.763Z"},"accession":"S-EPMC11415074","cross_references":{"pubmed":["39302097"],"doi":["10.7554/eLife.88256"]}}