{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Kim SK"],"funding":["NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["Microtubule (MT) regulation is essential for oocyte development. In <i>Drosophila</i>, MT stability, polarity, abundance, and orientation undergo dynamic changes across developmental stages. In our effort to identify novel microtubule-associated proteins (MAPs) that regulate MTs in the <i>Drosophila</i> ovary, we identified a previously uncharacterized gene, CG18190, encoding a novel MT end-binding (EB) protein, which we propose to name EB-SUN. We show that EB-SUN colocalizes with EB1 at growing microtubule plus-ends in <i>Drosophila</i> S2 cells. Tissue-specific and developmental expression profiles from Paralog Explorer reveal that EB-SUN is predominantly expressed in the ovary and early embryos, while EB1 is ubiquitously expressed. Furthermore, as early as oocyte determination, EB-SUN c"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.09.11.612465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11419005"],"repository":["biostudies-literature"],"pubmed_title":["EB-SUN, a New Microtubule Plus-End Tracking Protein in &lt;i&gt;Drosophila&lt;/i&gt;."],"pmcid":["PMC11419005"],"funding_grant_id":["R35 GM131752","P40 OD018537"],"pubmed_authors":["Lu W","Lee BS","Rogers SL","Kim SK","Gelfand VI"],"additional_accession":[]},"is_claimable":false,"name":"EB-SUN, a New Microtubule Plus-End Tracking Protein in &lt;i&gt;Drosophila&lt;/i&gt;.","description":"Microtubule (MT) regulation is essential for oocyte development. In <i>Drosophila</i>, MT stability, polarity, abundance, and orientation undergo dynamic changes across developmental stages. In our effort to identify novel microtubule-associated proteins (MAPs) that regulate MTs in the <i>Drosophila</i> ovary, we identified a previously uncharacterized gene, CG18190, encoding a novel MT end-binding (EB) protein, which we propose to name EB-SUN. We show that EB-SUN colocalizes with EB1 at growing microtubule plus-ends in <i>Drosophila</i> S2 cells. Tissue-specific and developmental expression profiles from Paralog Explorer reveal that EB-SUN is predominantly expressed in the ovary and early embryos, while EB1 is ubiquitously expressed. Furthermore, as early as oocyte determination, EB-SUN c","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-19T18:15:00.031Z","creation":"2025-04-19T18:15:00.031Z"},"accession":"S-EPMC11419005","cross_references":{"pubmed":["39314338"],"doi":["10.1101/2024.09.11.612465"]}}