biostudies-literatureUnknownZhang-James YNIMH NIH HHSNINDS NIH HHSNIAMS NIH HHS<h4>Importance</h4>Intermittent Explosive Disorder (IED) is an understudied psychiatric condition that presents with repeated episodes of impulsive aggression and poorly regulated emotional control, often resulting in interpersonal and societal consequences. Better understanding of comorbidities will allow for enhanced screening, diagnosis, and treatment of patients.<h4>Objective</h4>To investigate prevalence and associations of IED with psychiatric, neurological, and somatic disorders using real-world data.<h4>Design</h4>Matched cohorts of patients with or without IED diagnosis were identified using data from the TriNetX Research Network (until January 31, 2024). Cox proportional hazard models were used to estimate and compare the probabilities of acquiring other diagnoses using patients'medRxiv : the preprint server for health sciences2024.09.12.24313553https://www.ebi.ac.uk/biostudies/studies/S-EPMC11419232biostudies-literaturePsychiatric, Neurological, and Somatic Comorbidities in Intermittent Explosive Disorder: a retrospective cohort study of electronic health records.PMC11419232R01 MH130899U01 AR076092R01 NS128535U01 MH135970R01 MH116037R01 MH131685Strayhorn JFaraone SVZhang-James YPaliakkara JSchaeffer JfalsePsychiatric, Neurological, and Somatic Comorbidities in Intermittent Explosive Disorder: a retrospective cohort study of electronic health records.<h4>Importance</h4>Intermittent Explosive Disorder (IED) is an understudied psychiatric condition that presents with repeated episodes of impulsive aggression and poorly regulated emotional control, often resulting in interpersonal and societal consequences. Better understanding of comorbidities will allow for enhanced screening, diagnosis, and treatment of patients.<h4>Objective</h4>To investigate prevalence and associations of IED with psychiatric, neurological, and somatic disorders using real-world data.<h4>Design</h4>Matched cohorts of patients with or without IED diagnosis were identified using data from the TriNetX Research Network (until January 31, 2024). Cox proportional hazard models were used to estimate and compare the probabilities of acquiring other diagnoses using patients'2024-01-01T00:00:00Z2024 Sep2026-06-14T03:20:11.963Z2025-04-04T02:20:33.688ZS-EPMC114192323931497210.1101/2024.09.12.24313553