{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["42(7)"],"submitter":["Supriya M"],"pubmed_abstract":["The molecular mechanisms behind the rupture of intracranial aneurysms remain obscure. MiRNAs are key regulators of a wide array of biological processes altering protein synthesis by binding to target mRNAs. However, variations in miRNA levels in ruptured aneurysmal wall have not been completely examined. We hypothesized that altered miRNA signature in aneurysmal tissues could potentially provide insight into aneurysm pathophysiology. Using a high-throughput miRNA microarray screening approach, we compared the miRNA expression pattern in aneurysm tissues obtained during surgery from patients with aneurysmal subarachnoid hemorrhage (aSAH) with control tissues (GEO accession number GSE161870). We found that the expression of 70 miRNAs was altered. Expressions of the top 10 miRNA were validate"],"journal":["Cellular and molecular neurobiology"],"pagination":["2393-2405"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11421602"],"repository":["biostudies-literature"],"pubmed_title":["Altered MicroRNA Expression in Intracranial Aneurysmal Tissues: Possible Role in TGF-β Signaling Pathway."],"pmcid":["PMC11421602"],"pubmed_authors":["Supriya M","Shukla D","Devi BI","Bhat DI","Christopher R","Kalpana SR"],"additional_accession":[]},"is_claimable":false,"name":"Altered MicroRNA Expression in Intracranial Aneurysmal Tissues: Possible Role in TGF-β Signaling Pathway.","description":"The molecular mechanisms behind the rupture of intracranial aneurysms remain obscure. MiRNAs are key regulators of a wide array of biological processes altering protein synthesis by binding to target mRNAs. However, variations in miRNA levels in ruptured aneurysmal wall have not been completely examined. We hypothesized that altered miRNA signature in aneurysmal tissues could potentially provide insight into aneurysm pathophysiology. Using a high-throughput miRNA microarray screening approach, we compared the miRNA expression pattern in aneurysm tissues obtained during surgery from patients with aneurysmal subarachnoid hemorrhage (aSAH) with control tissues (GEO accession number GSE161870). We found that the expression of 70 miRNAs was altered. Expressions of the top 10 miRNA were validate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-01T08:51:35.747Z","creation":"2025-04-04T00:04:07.358Z"},"accession":"S-EPMC11421602","cross_references":{"pubmed":["34185228"],"doi":["10.1007/s10571-021-01121-3"]}}