biostudies-literatureXavier Hall CDNIMH NIH HHS631https://www.ebi.ac.uk/biostudies/studies/S-EPMC11428577biostudies-literatureUnknown25(1)<h4>Background</h4>The Ryan White Medical Case Management System, which serves more than half of people living with HIV (PLWH) in the USA, is an opportune setting for identifying and addressing depression among PLWH. A growing body of research suggests that interventions that promote positive emotion may lessen symptoms of depression and improve physical and psychological well-being among people experiencing a variety of health-related stress, including living with HIV. Research on how best to integrate standardized mental health screening and referral to evidence-based interventions in Ryan White Medical Case Management settings has the potential to improve the health and wellbeing of PLWH.<h4>Methods</h4>This mixed-methods study will enroll up to N = 300 Ryan White clients who screen posTrialsA hybrid type II effectiveness-implementation trial of a positive emotion regulation intervention among people living with HIV engaged in Ryan White Medical Case Management: protocol and design for the ORCHID study.PMC11428577R01 MH124632Cummings PMoskowitz JTXavier Hall CDAbujado FBannon JDerricotte DHirschhorn LRBouris AFreeman ADakin ABovbjerg KEthier KBouacha NPatterson LfalseA hybrid type II effectiveness-implementation trial of a positive emotion regulation intervention among people living with HIV engaged in Ryan White Medical Case Management: protocol and design for the ORCHID study.<h4>Background</h4>The Ryan White Medical Case Management System, which serves more than half of people living with HIV (PLWH) in the USA, is an opportune setting for identifying and addressing depression among PLWH. A growing body of research suggests that interventions that promote positive emotion may lessen symptoms of depression and improve physical and psychological well-being among people experiencing a variety of health-related stress, including living with HIV. Research on how best to integrate standardized mental health screening and referral to evidence-based interventions in Ryan White Medical Case Management settings has the potential to improve the health and wellbeing of PLWH.<h4>Methods</h4>This mixed-methods study will enroll up to N = 300 Ryan White clients who screen pos2024-01-01T00:00:00Z2024 Sep2026-06-01T13:45:16.615Z2025-04-04T12:53:34.296ZS-EPMC114285773933447210.1186/s13063-024-08475-1