{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiang B"],"funding":["Bureau of Science and Technology of Guangzhou Municipality","\"Jie Bang Gua Shuai\" project of The Sixth Affiliated Hospital of Sun Yat-sen University","Guangdong Province “Pearl River Talent Plan” Innovation and Entrepreneurship Team Project","National Natural Science Foundation of China","the Sun Yat-sen University Clinical Research 5010 Program","Guangdong Province \"Pearl River Talent Plan\" Innovation and Entrepreneurship Team Project","the Bureau of Science and Technology of Guangzhou Municipality","Sun Yat-sen University Clinical Research 5010 Program","the National Natural Science Foundation of China","the program of Guangdong Provincial Clinical Research Center for Digestive Diseases","program of Guangdong Provincial Clinical Research Center for Digestive Diseases","“Jie Bang Gua Shuai” project of The Sixth Affiliated Hospital of Sun Yat-sen University"],"pagination":["2103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(9)"],"pubmed_abstract":["The impact of coronavirus disease 2019 (COVID-19) history on Crohn's disease (CD) is unknown. This investigation aimed to examine the effect of COVID-19 history on the disease course, oral-gut microbiota, and serum metabolomics in patients with CD. In this study, oral-gut microbiota and serum metabolomic profiles in 30 patients with CD and a history of mild COVID-19 (positive group, PG), 30 patients with CD without COVID-19 history (negative group, NG), and 60 healthy controls (HC) were assessed using 16S rDNA sequencing and targeted metabolomics. During follow-up, the CD activity index showed a stronger decrease in the PG than in the NG (<i>p</i> = 0.0496). PG patients demonstrated higher α-diversity and distinct β-diversity clustering in both salivary and fecal microbiota compared to NG "],"journal":["Biomedicines"],"pubmed_title":["Impact of Mild COVID-19 History on Oral-Gut Microbiota and Serum Metabolomics in Adult Patients with Crohn's Disease: Potential Beneficial Effects."],"pmcid":["PMC11429124"],"funding_grant_id":["2022JBGS06","2022JBGS06 (MZ)","SL2022B03J00237 (MZ)","2020B1111170004 (MZ)","82270544 (MZ)","2019ZT08Y464","2020B1111170004","SL2022B03J00237","2014008","2019ZT08Y464 (LZ)","82270544","2014008 (MZ)"],"pubmed_authors":["Xiang B","Hu J","Zhu L","Zhang M","Lin J","Zhi M","Zhang Q","Xu Z","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Mild COVID-19 History on Oral-Gut Microbiota and Serum Metabolomics in Adult Patients with Crohn's Disease: Potential Beneficial Effects.","description":"The impact of coronavirus disease 2019 (COVID-19) history on Crohn's disease (CD) is unknown. This investigation aimed to examine the effect of COVID-19 history on the disease course, oral-gut microbiota, and serum metabolomics in patients with CD. In this study, oral-gut microbiota and serum metabolomic profiles in 30 patients with CD and a history of mild COVID-19 (positive group, PG), 30 patients with CD without COVID-19 history (negative group, NG), and 60 healthy controls (HC) were assessed using 16S rDNA sequencing and targeted metabolomics. During follow-up, the CD activity index showed a stronger decrease in the PG than in the NG (<i>p</i> = 0.0496). PG patients demonstrated higher α-diversity and distinct β-diversity clustering in both salivary and fecal microbiota compared to NG ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-05-14T03:11:53.083Z","creation":"2025-04-04T01:14:26.961Z"},"accession":"S-EPMC11429124","cross_references":{"pubmed":["39335616"],"doi":["10.3390/biomedicines12092103"]}}