biostudies-literatureXiang BBureau of Science and Technology of Guangzhou Municipality"Jie Bang Gua Shuai" project of The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangdong Province “Pearl River Talent Plan” Innovation and Entrepreneurship Team ProjectNational Natural Science Foundation of Chinathe Sun Yat-sen University Clinical Research 5010 ProgramGuangdong Province "Pearl River Talent Plan" Innovation and Entrepreneurship Team Projectthe Bureau of Science and Technology of Guangzhou MunicipalitySun Yat-sen University Clinical Research 5010 Programthe National Natural Science Foundation of Chinathe program of Guangdong Provincial Clinical Research Center for Digestive Diseasesprogram of Guangdong Provincial Clinical Research Center for Digestive Diseases“Jie Bang Gua Shuai” project of The Sixth Affiliated Hospital of Sun Yat-sen University2103https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429124biostudies-literatureUnknown12(9)The impact of coronavirus disease 2019 (COVID-19) history on Crohn's disease (CD) is unknown. This investigation aimed to examine the effect of COVID-19 history on the disease course, oral-gut microbiota, and serum metabolomics in patients with CD. In this study, oral-gut microbiota and serum metabolomic profiles in 30 patients with CD and a history of mild COVID-19 (positive group, PG), 30 patients with CD without COVID-19 history (negative group, NG), and 60 healthy controls (HC) were assessed using 16S rDNA sequencing and targeted metabolomics. During follow-up, the CD activity index showed a stronger decrease in the PG than in the NG (<i>p</i> = 0.0496). PG patients demonstrated higher α-diversity and distinct β-diversity clustering in both salivary and fecal microbiota compared to NG BiomedicinesImpact of Mild COVID-19 History on Oral-Gut Microbiota and Serum Metabolomics in Adult Patients with Crohn's Disease: Potential Beneficial Effects.PMC114291242022JBGS062022JBGS06 (MZ)SL2022B03J00237 (MZ)2020B1111170004 (MZ)82270544 (MZ)2019ZT08Y4642020B1111170004SL2022B03J0023720140082019ZT08Y464 (LZ)822705442014008 (MZ)Xiang BHu JZhu LZhang MLin JZhi MZhang QXu ZWu HfalseImpact of Mild COVID-19 History on Oral-Gut Microbiota and Serum Metabolomics in Adult Patients with Crohn's Disease: Potential Beneficial Effects.The impact of coronavirus disease 2019 (COVID-19) history on Crohn's disease (CD) is unknown. This investigation aimed to examine the effect of COVID-19 history on the disease course, oral-gut microbiota, and serum metabolomics in patients with CD. In this study, oral-gut microbiota and serum metabolomic profiles in 30 patients with CD and a history of mild COVID-19 (positive group, PG), 30 patients with CD without COVID-19 history (negative group, NG), and 60 healthy controls (HC) were assessed using 16S rDNA sequencing and targeted metabolomics. During follow-up, the CD activity index showed a stronger decrease in the PG than in the NG (<i>p</i> = 0.0496). PG patients demonstrated higher α-diversity and distinct β-diversity clustering in both salivary and fecal microbiota compared to NG 2024-01-01T00:00:00Z2024 Sep2026-05-14T03:11:53.083Z2025-04-04T01:14:26.961ZS-EPMC114291243933561610.3390/biomedicines12092103