{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(9)"],"submitter":["Zazo H"],"pubmed_abstract":["<i>P. aeruginosa</i> is the most common microorganism involved in many ICU-acquired infections. A correct dosage regimen is pivotal to avoiding resistance development, worse outcomes and higher mortality rates. The aim of this study was to perform a pharmacokinetic-pharmacodynamic (PK/PD) evaluation of recommended dosing regimens of ceftazidime-avibactam (CAZ-AVI) in ICU patients with different degrees of renal function for a specific strain of <i>Pseudomonas aeruginosa</i>. A semi-mechanistic PK/PD model has been developed. It allows for the simulation of CAZ-AVI steady-state plasma level curves and the evolution of bacterial growth curves. The percentage of bacterial load reduction and the value of the recommended PK/PD indices have been taken into account to define the success or failur"],"journal":["Antibiotics (Basel, Switzerland)"],"pagination":["861"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429409"],"repository":["biostudies-literature"],"pubmed_title":["Dosing Evaluation of Ceftazidime-Avibactam in Intensive Care Unit Patients Based on Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling and Simulation."],"pmcid":["PMC11429409"],"pubmed_authors":["Zazo H","Lanao JM","Aguazul Y"],"additional_accession":[]},"is_claimable":false,"name":"Dosing Evaluation of Ceftazidime-Avibactam in Intensive Care Unit Patients Based on Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling and Simulation.","description":"<i>P. aeruginosa</i> is the most common microorganism involved in many ICU-acquired infections. A correct dosage regimen is pivotal to avoiding resistance development, worse outcomes and higher mortality rates. The aim of this study was to perform a pharmacokinetic-pharmacodynamic (PK/PD) evaluation of recommended dosing regimens of ceftazidime-avibactam (CAZ-AVI) in ICU patients with different degrees of renal function for a specific strain of <i>Pseudomonas aeruginosa</i>. A semi-mechanistic PK/PD model has been developed. It allows for the simulation of CAZ-AVI steady-state plasma level curves and the evolution of bacterial growth curves. The percentage of bacterial load reduction and the value of the recommended PK/PD indices have been taken into account to define the success or failur","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T01:54:01.079Z","creation":"2025-04-04T01:54:01.079Z"},"accession":"S-EPMC11429409","cross_references":{"pubmed":["39335034"],"doi":["10.3390/antibiotics13090861"]}}