{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["McDaniel JH"],"funding":["NHGRI NIH HHS","NCI NIH HHS","NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first to be explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, and Hi-C, and karyotyping. In future publications, these data will be used"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.09.18.613544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429686"],"repository":["biostudies-literature"],"pubmed_title":["Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair."],"pmcid":["PMC11429686"],"funding_grant_id":["U01 CA253405","S10 OD028587","OT2 OD034190","R44 HG014126","R35 GM133747","R01 HG011274","U24 HG011853"],"pubmed_authors":["Shelton J","Akeson S","Paten B","Ahmad T","Lambert C","Mehta H","Steinsnyder Z","Krieger G","Husar G","Remington J","Proszynski J","Cole KD","Sudkamp M","Hirschberg JW","Catreux S","Park J","Iremadze N","Jain M","Bhakta MS","Patel V","Violich I","Wagner J","Sikkink K","Rojas A","Scheffler K","Lajoie BR","Hannah LC","Kennedy K","Wenger AM","Eacker S","Keskus A","He Z","Narzisi G","Rosen GL","Levy S","McLaughlin IJ","Truong S","Zachary Sanborn J","He HJ","Sedlazeck FJ","McDaniel JH","Bayabyan P","Yu HC","Jhangiani SN","Bryant A","McNulty B","Salas-Gonzalez I","Lipson D","Thibaud-Nissen F","Wiseman K","Vernich M","Wescott M","Cross E","Munding EM","Behera S","Hastie AR","Paulin LF","Soifer I","Doddapaneni H","Trow J","Gross S","Miga KH","Muzny DM","Benjamin H","Mason CE","Olson ND","Reeves C","Kolmogorov M","Gingras MC","Kingan SB","Gardner J","Gooden AA","Kingsley C","Weigman V","Sayyari E","Brundu F","Kim Y","McCoy R","Liss AS","Zook JM","Ryon K","Xiao C","Schmitt A","Adamson A","Wood M"],"additional_accession":[]},"is_claimable":false,"name":"Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair.","description":"The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first to be explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, and Hi-C, and karyotyping. In future publications, these data will be used","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-05-17T03:14:27.014Z","creation":"2025-04-04T00:45:46.504Z"},"accession":"S-EPMC11429686","cross_references":{"pubmed":["39345378"],"doi":["10.1101/2024.09.18.613544"]}}