biostudies-literatureUnknownMcDaniel JHNHGRI NIH HHSNCI NIH HHSNIH HHSNIGMS NIH HHSThe Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first to be explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, and Hi-C, and karyotyping. In future publications, these data will be usedbioRxiv : the preprint server for biology2024.09.18.613544https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429686biostudies-literatureDevelopment and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair.PMC11429686U01 CA253405S10 OD028587OT2 OD034190R44 HG014126R35 GM133747R01 HG011274U24 HG011853Shelton JAkeson SPaten BAhmad TLambert CMehta HSteinsnyder ZKrieger GHusar GRemington JProszynski JCole KDSudkamp MHirschberg JWCatreux SPark JIremadze NJain MBhakta MSPatel VViolich IWagner JSikkink KRojas AScheffler KLajoie BRHannah LCKennedy KWenger AMEacker SKeskus AHe ZNarzisi GRosen GLLevy SMcLaughlin IJTruong SZachary Sanborn JHe HJSedlazeck FJMcDaniel JHBayabyan PYu HCJhangiani SNBryant AMcNulty BSalas-Gonzalez ILipson DThibaud-Nissen FWiseman KVernich MWescott MCross EMunding EMBehera SHastie ARPaulin LFSoifer IDoddapaneni HTrow JGross SMiga KHMuzny DMBenjamin HMason CEOlson NDReeves CKolmogorov MGingras MCKingan SBGardner JGooden AAKingsley CWeigman VSayyari EBrundu FKim YMcCoy RLiss ASZook JMRyon KXiao CSchmitt AAdamson AWood MfalseDevelopment and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair.The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first to be explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, and Hi-C, and karyotyping. In future publications, these data will be used2025-01-01T00:00:00Z2025 Jun2026-05-17T03:14:27.014Z2025-04-04T00:45:46.504ZS-EPMC114296863934537810.1101/2024.09.18.613544