{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["El Din DA"],"funding":["NIEHS NIH HHS","NIH HHS"],"pubmed_abstract":["Brain Microphysiological Systems including neural organoids derived from human induced pluripotent stem cells offer a unique lens to study the intricate workings of the human brain. This paper investigates the foundational elements of learning and memory in neural organoids, also known as Organoid Intelligence by quantifying immediate early gene expression, synaptic plasticity, neuronal network dynamics, and criticality to demonstrate the utility of these organoids in basic science research. Neural organoids showed synapse formation, glutamatergic and GABAergic receptor expression, immediate early gene expression basally and evoked, functional connectivity, criticality, and synaptic plasticity in response to theta-burst stimulation. In addition, pharmacological interventions on GABAergic a"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.09.17.613333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11429697"],"repository":["biostudies-literature"],"pubmed_title":["Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and Memory."],"pmcid":["PMC11429697"],"funding_grant_id":["S10 OD025244","T32 ES007141"],"pubmed_authors":["Loeffler A","Habibollahi F","Smirnova L","Hartung T","Kagan BJ","Mitra A","Laird J","Johnson EC","Ding L","Schenke M","El Din DA","Schenkman J","van der Molen T","Moenkemoeller L"],"additional_accession":[]},"is_claimable":false,"name":"Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and Memory.","description":"Brain Microphysiological Systems including neural organoids derived from human induced pluripotent stem cells offer a unique lens to study the intricate workings of the human brain. This paper investigates the foundational elements of learning and memory in neural organoids, also known as Organoid Intelligence by quantifying immediate early gene expression, synaptic plasticity, neuronal network dynamics, and criticality to demonstrate the utility of these organoids in basic science research. Neural organoids showed synapse formation, glutamatergic and GABAergic receptor expression, immediate early gene expression basally and evoked, functional connectivity, criticality, and synaptic plasticity in response to theta-burst stimulation. In addition, pharmacological interventions on GABAergic a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-04-07T20:19:01.73Z","creation":"2025-04-04T20:55:48.794Z"},"accession":"S-EPMC11429697","cross_references":{"pubmed":["39345518"],"doi":["10.1101/2024.09.17.613333"]}}