{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Astone M"],"funding":["European Union - NextGenerationEU- PNRR - M4C2-I1.3"],"pagination":["10005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(18)"],"pubmed_abstract":["Hippo-YAP/TAZ and Wnt/β-catenin signaling pathways, by controlling proliferation, migration, cell fate, stemness, and apoptosis, are crucial regulators of development and tissue homeostasis. We employed zebrafish embryos as a model system to elucidate in living reporter organisms the crosstalk between the two signaling pathways. Co-expression analysis between the Wnt/β-catenin <i>Tg(7xTCF-Xla.Siam:GFP)<sup>ia4</sup></i> and the Hippo-Yap/Taz <i>Tg(Hsa.CTGF:nlsmCherry)<sup>ia49</sup></i> zebrafish reporter lines revealed shared spatiotemporal expression profiles. These patterns were particularly evident in key developmental regions such as the midbrain-hindbrain boundary (MHB), epidermis, muscles, neural tube, notochord, floorplate, and otic vesicle. To investigate the relationship between "],"journal":["International journal of molecular sciences"],"pubmed_title":["Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish."],"pmcid":["PMC11432159"],"funding_grant_id":["Project PE_00000019 \"HEAL ITALIA\", CUP (B33C22001030006)"],"pubmed_authors":["Schiavone M","Vettori A","Argenton F","Facchinello N","Astone M","Tiso N","Tesoriero C"],"additional_accession":[]},"is_claimable":false,"name":"Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish.","description":"Hippo-YAP/TAZ and Wnt/β-catenin signaling pathways, by controlling proliferation, migration, cell fate, stemness, and apoptosis, are crucial regulators of development and tissue homeostasis. We employed zebrafish embryos as a model system to elucidate in living reporter organisms the crosstalk between the two signaling pathways. Co-expression analysis between the Wnt/β-catenin <i>Tg(7xTCF-Xla.Siam:GFP)<sup>ia4</sup></i> and the Hippo-Yap/Taz <i>Tg(Hsa.CTGF:nlsmCherry)<sup>ia49</sup></i> zebrafish reporter lines revealed shared spatiotemporal expression profiles. These patterns were particularly evident in key developmental regions such as the midbrain-hindbrain boundary (MHB), epidermis, muscles, neural tube, notochord, floorplate, and otic vesicle. To investigate the relationship between ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T02:43:18.616Z","creation":"2025-04-04T02:43:18.616Z"},"accession":"S-EPMC11432159","cross_references":{"pubmed":["39337493"],"doi":["10.3390/ijms251810005"]}}