biostudies-literatureAstone MEuropean Union - NextGenerationEU- PNRR - M4C2-I1.310005https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432159biostudies-literatureUnknown25(18)Hippo-YAP/TAZ and Wnt/β-catenin signaling pathways, by controlling proliferation, migration, cell fate, stemness, and apoptosis, are crucial regulators of development and tissue homeostasis. We employed zebrafish embryos as a model system to elucidate in living reporter organisms the crosstalk between the two signaling pathways. Co-expression analysis between the Wnt/β-catenin <i>Tg(7xTCF-Xla.Siam:GFP)^ia4</i> and the Hippo-Yap/Taz <i>Tg(Hsa.CTGF:nlsmCherry)^ia49</i> zebrafish reporter lines revealed shared spatiotemporal expression profiles. These patterns were particularly evident in key developmental regions such as the midbrain-hindbrain boundary (MHB), epidermis, muscles, neural tube, notochord, floorplate, and otic vesicle. To investigate the relationship between International journal of molecular sciencesWnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish.PMC11432159Project PE_00000019 "HEAL ITALIA", CUP (B33C22001030006)Schiavone MVettori AArgenton FFacchinello NAstone MTiso NTesoriero CfalseWnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish.Hippo-YAP/TAZ and Wnt/β-catenin signaling pathways, by controlling proliferation, migration, cell fate, stemness, and apoptosis, are crucial regulators of development and tissue homeostasis. We employed zebrafish embryos as a model system to elucidate in living reporter organisms the crosstalk between the two signaling pathways. Co-expression analysis between the Wnt/β-catenin <i>Tg(7xTCF-Xla.Siam:GFP)^ia4</i> and the Hippo-Yap/Taz <i>Tg(Hsa.CTGF:nlsmCherry)^ia49</i> zebrafish reporter lines revealed shared spatiotemporal expression profiles. These patterns were particularly evident in key developmental regions such as the midbrain-hindbrain boundary (MHB), epidermis, muscles, neural tube, notochord, floorplate, and otic vesicle. To investigate the relationship between 2024-01-01T00:00:00Z2024 Sep2025-04-04T02:43:18.616Z2025-04-04T02:43:18.616ZS-EPMC114321593933749310.3390/ijms251810005