{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(18)"],"submitter":["Vadeikiene R"],"pubmed_abstract":["Myeloproliferative neoplasms (MPNs) are characterized by increased proliferation of myeloid lineages in the bone marrow. Calreticulin (<i>CALR</i>) 52 bp deletion and <i>CALR</i> 5 bp insertion have been identified in essential thrombocythemia (ET) and primary myelofibrosis (PMF). There is not much data on the crosstalk between mutated <i>CALR</i> and MPN-related signaling pathways, such as JAK/STAT, PI3K/Akt/mTOR, and Hedgehog. Calreticulin, a multifunctional protein, takes part in many cellular processes. Nevertheless, there is little data on how mutated <i>CALR</i> affects the oxidative stress response and oxidative stress-induced DNA damage, apoptosis, and cell cycle progression. We aimed to investigate the role of the <i>CALR</i> 52 bp deletion and 5 bp insertion in the pathogenesis o"],"journal":["International journal of molecular sciences"],"pagination":["9873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432199"],"repository":["biostudies-literature"],"pubmed_title":["The Role of Mutated Calreticulin in the Pathogenesis of <i>BCR-ABL1</i>-Negative Myeloproliferative Neoplasms."],"pmcid":["PMC11432199"],"pubmed_authors":["Laukaitiene D","Vadeikiene R","Satkauskas S","Ugenskiene R","Jakstys B","Juozaityte E"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Mutated Calreticulin in the Pathogenesis of <i>BCR-ABL1</i>-Negative Myeloproliferative Neoplasms.","description":"Myeloproliferative neoplasms (MPNs) are characterized by increased proliferation of myeloid lineages in the bone marrow. Calreticulin (<i>CALR</i>) 52 bp deletion and <i>CALR</i> 5 bp insertion have been identified in essential thrombocythemia (ET) and primary myelofibrosis (PMF). There is not much data on the crosstalk between mutated <i>CALR</i> and MPN-related signaling pathways, such as JAK/STAT, PI3K/Akt/mTOR, and Hedgehog. Calreticulin, a multifunctional protein, takes part in many cellular processes. Nevertheless, there is little data on how mutated <i>CALR</i> affects the oxidative stress response and oxidative stress-induced DNA damage, apoptosis, and cell cycle progression. We aimed to investigate the role of the <i>CALR</i> 52 bp deletion and 5 bp insertion in the pathogenesis o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-05-14T03:15:49.825Z","creation":"2025-04-07T07:39:02.244Z"},"accession":"S-EPMC11432199","cross_references":{"pubmed":["39337361"],"doi":["10.3390/ijms25189873"]}}