biostudies-literatureUnknown25(18)Vadeikiene RMyeloproliferative neoplasms (MPNs) are characterized by increased proliferation of myeloid lineages in the bone marrow. Calreticulin (<i>CALR</i>) 52 bp deletion and <i>CALR</i> 5 bp insertion have been identified in essential thrombocythemia (ET) and primary myelofibrosis (PMF). There is not much data on the crosstalk between mutated <i>CALR</i> and MPN-related signaling pathways, such as JAK/STAT, PI3K/Akt/mTOR, and Hedgehog. Calreticulin, a multifunctional protein, takes part in many cellular processes. Nevertheless, there is little data on how mutated <i>CALR</i> affects the oxidative stress response and oxidative stress-induced DNA damage, apoptosis, and cell cycle progression. We aimed to investigate the role of the <i>CALR</i> 52 bp deletion and 5 bp insertion in the pathogenesis oInternational journal of molecular sciences9873https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432199biostudies-literatureThe Role of Mutated Calreticulin in the Pathogenesis of <i>BCR-ABL1</i>-Negative Myeloproliferative Neoplasms.PMC11432199Laukaitiene DVadeikiene RSatkauskas SUgenskiene RJakstys BJuozaityte EfalseThe Role of Mutated Calreticulin in the Pathogenesis of <i>BCR-ABL1</i>-Negative Myeloproliferative Neoplasms.Myeloproliferative neoplasms (MPNs) are characterized by increased proliferation of myeloid lineages in the bone marrow. Calreticulin (<i>CALR</i>) 52 bp deletion and <i>CALR</i> 5 bp insertion have been identified in essential thrombocythemia (ET) and primary myelofibrosis (PMF). There is not much data on the crosstalk between mutated <i>CALR</i> and MPN-related signaling pathways, such as JAK/STAT, PI3K/Akt/mTOR, and Hedgehog. Calreticulin, a multifunctional protein, takes part in many cellular processes. Nevertheless, there is little data on how mutated <i>CALR</i> affects the oxidative stress response and oxidative stress-induced DNA damage, apoptosis, and cell cycle progression. We aimed to investigate the role of the <i>CALR</i> 52 bp deletion and 5 bp insertion in the pathogenesis o2024-01-01T00:00:00Z2024 Sep2026-05-14T03:15:49.825Z2025-04-07T07:39:02.244ZS-EPMC114321993933736110.3390/ijms25189873