biostudies-literatureDi Pietro BMinistero dell'Università e della Ricerca (MUR)Area Science Park9808https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432240biostudies-literatureUnknown25(18)The therapeutic usage of physical stimuli is framed in a highly heterogeneous research area, with variable levels of maturity and of translatability into clinical application. In particular, electrostimulation is deeply studied for its application on the autonomous nervous system, but less is known about the anti- inflammatory effects of such stimuli beyond the <i>inflammatory reflex</i>. Further, reproducibility and meta-analyses are extremely challenging, owing to the limited rationale on dosage and experimental standardization. It is specifically to address the fundamental question on the anti-inflammatory effects of electricity on biological systems, that we propose a series of controlled experiments on the effects of direct and alternate current delivered on a standardized 3D bioconstInternational journal of molecular sciencesDifferential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting.PMC11432240IR0000009prot. aooarea/2020/000477Dal Monego SAngelini CNapione LManni LGuarnieri TDi Pietro BTenori LPecchioli VNardini CLiu YDegasperi MGhini VPlaksienko ALicastro DVillata SFrascella FfalseDifferential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting.The therapeutic usage of physical stimuli is framed in a highly heterogeneous research area, with variable levels of maturity and of translatability into clinical application. In particular, electrostimulation is deeply studied for its application on the autonomous nervous system, but less is known about the anti- inflammatory effects of such stimuli beyond the <i>inflammatory reflex</i>. Further, reproducibility and meta-analyses are extremely challenging, owing to the limited rationale on dosage and experimental standardization. It is specifically to address the fundamental question on the anti-inflammatory effects of electricity on biological systems, that we propose a series of controlled experiments on the effects of direct and alternate current delivered on a standardized 3D bioconst2024-01-01T00:00:00Z2024 Sep2026-07-05T03:09:35.366Z2025-04-04T02:19:52.885ZS-EPMC114322403933730010.3390/ijms25189808