{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(18)"],"submitter":["Gaige S"],"pubmed_abstract":["Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites with different chemical moieties. Here, we generated an artificial chalcone, i.e., 3,5-dimethyl-2,4,6-trimethoxychalcone (TriMetChalc), derived from 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC). DMC is a major compound of <i>Cleistocalyx operculatus</i>, a plant widely used in Asia for its anti-hyperglycemic activity. Using <i>ob/ob</i> mice as an obesity model, we report that, after 3 weeks of <i>per os</i> administration, TriMetChalc modified food intake through the specifi"],"journal":["International journal of molecular sciences"],"pagination":["9838"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432508"],"repository":["biostudies-literature"],"pubmed_title":["3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient &lt;i&gt;ob/ob&lt;/i&gt; Mice."],"pmcid":["PMC11432508"],"pubmed_authors":["Gaige S","Barbouche R","Tonetto A","Robin M","Abysique A","Troadec JD","Di Maio A","Lormier AT"],"additional_accession":[]},"is_claimable":false,"name":"3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient &lt;i&gt;ob/ob&lt;/i&gt; Mice.","description":"Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites with different chemical moieties. Here, we generated an artificial chalcone, i.e., 3,5-dimethyl-2,4,6-trimethoxychalcone (TriMetChalc), derived from 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC). DMC is a major compound of <i>Cleistocalyx operculatus</i>, a plant widely used in Asia for its anti-hyperglycemic activity. Using <i>ob/ob</i> mice as an obesity model, we report that, after 3 weeks of <i>per os</i> administration, TriMetChalc modified food intake through the specifi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-03T23:48:21.499Z","creation":"2025-04-03T23:48:21.499Z"},"accession":"S-EPMC11432508","cross_references":{"pubmed":["39337328"],"doi":["10.3390/ijms25189838"]}}