biostudies-literatureUnknown25(18)Gaige SChalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites with different chemical moieties. Here, we generated an artificial chalcone, i.e., 3,5-dimethyl-2,4,6-trimethoxychalcone (TriMetChalc), derived from 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC). DMC is a major compound of <i>Cleistocalyx operculatus</i>, a plant widely used in Asia for its anti-hyperglycemic activity. Using <i>ob/ob</i> mice as an obesity model, we report that, after 3 weeks of <i>per os</i> administration, TriMetChalc modified food intake through the specifiInternational journal of molecular sciences9838https://www.ebi.ac.uk/biostudies/studies/S-EPMC11432508biostudies-literature3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient &lt;i&gt;ob/ob&lt;/i&gt; Mice.PMC11432508Gaige SBarbouche RTonetto ARobin MAbysique ATroadec JDDi Maio ALormier ATfalse3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient &lt;i&gt;ob/ob&lt;/i&gt; Mice.Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites with different chemical moieties. Here, we generated an artificial chalcone, i.e., 3,5-dimethyl-2,4,6-trimethoxychalcone (TriMetChalc), derived from 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC). DMC is a major compound of <i>Cleistocalyx operculatus</i>, a plant widely used in Asia for its anti-hyperglycemic activity. Using <i>ob/ob</i> mice as an obesity model, we report that, after 3 weeks of <i>per os</i> administration, TriMetChalc modified food intake through the specifi2024-01-01T00:00:00Z2024 Sep2025-04-03T23:48:21.499Z2025-04-03T23:48:21.499ZS-EPMC114325083933732810.3390/ijms25189838