biostudies-literatureGuo Sthe Ningbo University Student Research and Innovation Programthe S&T Plan of Ningbo Science and Technology Departmentthe Science and Technology Innovation 2025 Major Project of Ningbo Citythe Fundamental Research Funds for the Provincial Universities of ZhejiangNational Natural Science Foundation of China1072https://www.ebi.ac.uk/biostudies/studies/S-EPMC11433682biostudies-literatureUnknown15(9)The triboelectric nanogenerator (TENG) has the potential to serve as a high-entropy energy harvester, enabling the self-powered operation of Internet of Things (IoT) devices. True random number generator (TRNG) is a common feature of encryption used in IoT data communication, ensuring the security of transmitted information. The benefits of multiplexing TENG and TRNG in resource-constrained IoT devices are substantial. However, current designs are limited by the usage scenarios and throughput of the TRNG. Specifically, we propose a structurally and environmentally friendly design based on the contact-separation structure, integrating heat fluctuation and charge decay as entropy sources. Furthermore, filtering and differential algorithms are recommended for data processing based on TENG chaMicromachinesA True Random Number Generator Design Based on the Triboelectric Nanogenerator with Multiple Entropy Sources.PMC11433682SJLY202001562174121, 61871244, 62134002202002N31342024SRIP13122022Z203Ruan ZPan YZhang YGuo SZhou ZWang LfalseA True Random Number Generator Design Based on the Triboelectric Nanogenerator with Multiple Entropy Sources.The triboelectric nanogenerator (TENG) has the potential to serve as a high-entropy energy harvester, enabling the self-powered operation of Internet of Things (IoT) devices. True random number generator (TRNG) is a common feature of encryption used in IoT data communication, ensuring the security of transmitted information. The benefits of multiplexing TENG and TRNG in resource-constrained IoT devices are substantial. However, current designs are limited by the usage scenarios and throughput of the TRNG. Specifically, we propose a structurally and environmentally friendly design based on the contact-separation structure, integrating heat fluctuation and charge decay as entropy sources. Furthermore, filtering and differential algorithms are recommended for data processing based on TENG cha2024-01-01T00:00:00Z2024 Aug2025-04-04T00:48:49.405Z2025-04-04T00:48:49.405ZS-EPMC114336823933773210.3390/mi15091072