{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song B"],"funding":["NCRR NIH HHS","NIMHD NIH HHS","NCI NIH HHS"],"pagination":["1374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11435809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(9)"],"pubmed_abstract":["The productive replication of human immunodeficiency virus type 1 (HIV-1) involves intricate interactions between viral proteins and host cell machinery. However, the contributions of the lysosomal pathways for HIV-1 replication are not fully understood. The goal of this study was to determine the impact of lysosome-targeting compounds on HIV-1 replication and identify the cellular changes that are linked to HIV-1 inhibition using cell culture models of HIV-1 infection. Here, we demonstrate that the treatment of cells with various pharmacological agents known to inhibit lysosomal functions interfere with HIV-1 replication. The vacuolar ATPase (V-ATPase) inhibitor bafilomycin A1 exerted a potent inhibition of HIV-1 replication. Bafilomycin A1 inhibition of HIV-1 was independent of corecepto"],"journal":["Viruses"],"pubmed_title":["Bafilomycin A1 Inhibits HIV-1 Infection by Disrupting Lysosomal Cholesterol Transport."],"pmcid":["PMC11435809"],"funding_grant_id":["U54 CA163069","U54 MD007586","S10 RR025497"],"pubmed_authors":["Song B","Korolkova O"],"additional_accession":[]},"is_claimable":false,"name":"Bafilomycin A1 Inhibits HIV-1 Infection by Disrupting Lysosomal Cholesterol Transport.","description":"The productive replication of human immunodeficiency virus type 1 (HIV-1) involves intricate interactions between viral proteins and host cell machinery. However, the contributions of the lysosomal pathways for HIV-1 replication are not fully understood. The goal of this study was to determine the impact of lysosome-targeting compounds on HIV-1 replication and identify the cellular changes that are linked to HIV-1 inhibition using cell culture models of HIV-1 infection. Here, we demonstrate that the treatment of cells with various pharmacological agents known to inhibit lysosomal functions interfere with HIV-1 replication. The vacuolar ATPase (V-ATPase) inhibitor bafilomycin A1 exerted a potent inhibition of HIV-1 replication. Bafilomycin A1 inhibition of HIV-1 was independent of corecepto","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-07-09T11:11:00.336Z","creation":"2025-04-04T23:41:46.691Z"},"accession":"S-EPMC11435809","cross_references":{"pubmed":["39339852"],"doi":["10.3390/v16091374"]}}