{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kriukov DV"],"funding":["Dutch Research Council (NWO)"],"pagination":["8289"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11436770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Networks of chemical reactions exhibit emergent properties under out-of-equilibrium conditions. Recent advances in systems chemistry demonstrate that networks with sufficient chemical complexity can be harnessed to emulate properties important for neuromorphic computing. In all examples, autocatalysis appears an essential element for facilitating the nonlinear integration of the input and self-regulatory abilities in the output. How this chemical analogue of a positive feedback mechanism can be controlled in a programmable manner is, however, unexplored. Here, we develop a strategy that uses metal ions (Ca<sup>2+</sup>, La<sup>3+</sup>, and Nd<sup>3+</sup>) to control the rate of a trypsin-catalysed autocatalytic reaction network. We demonstrate that this type of control allows for tuning "],"journal":["Nature communications"],"pubmed_title":["Exploring the programmability of autocatalytic chemical reaction networks."],"pmcid":["PMC11436770"],"funding_grant_id":["202.155"],"pubmed_authors":["Huskens J","Wong ASY","Kriukov DV"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the programmability of autocatalytic chemical reaction networks.","description":"Networks of chemical reactions exhibit emergent properties under out-of-equilibrium conditions. Recent advances in systems chemistry demonstrate that networks with sufficient chemical complexity can be harnessed to emulate properties important for neuromorphic computing. In all examples, autocatalysis appears an essential element for facilitating the nonlinear integration of the input and self-regulatory abilities in the output. How this chemical analogue of a positive feedback mechanism can be controlled in a programmable manner is, however, unexplored. Here, we develop a strategy that uses metal ions (Ca<sup>2+</sup>, La<sup>3+</sup>, and Nd<sup>3+</sup>) to control the rate of a trypsin-catalysed autocatalytic reaction network. We demonstrate that this type of control allows for tuning ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-05T08:58:42.693Z","creation":"2025-04-05T08:58:42.693Z"},"accession":"S-EPMC11436770","cross_references":{"pubmed":["39333532"],"doi":["10.1038/s41467-024-52649-z"]}}