{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang L"],"funding":["Guangdong Provincial Hospital of Chinese Medicine","The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund","Administration of Traditional Chinese Medicine of Guangdong Province","Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine","National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province","Guangdong College of Traditional Chinese Medicine"],"pagination":["282-291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11439983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(5)"],"pubmed_abstract":["<h4>Background</h4>Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.<h4>Objective</h4>This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.<h4>Methods</h4>We analyzed microarray data (GSE41662) to investigate the gene expression of <i>SKP2</i> in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-"],"journal":["Annals of dermatology"],"pubmed_title":["Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1."],"pmcid":["PMC11439983"],"funding_grant_id":["YN2024HL04","SZ2021ZZ23","YN2018QJ03","82004377","2020B1212030006","2024A1515030148","20222066","SZ2022QN10"],"pubmed_authors":["Li G","Liu H","Zheng X","Li C","Zhu Y","Huang H","Han W","Li Q","Wu D","Feng B","Liu T","Dai Z","Wang M","Tang L","Qiu X","Zhang Z","Zhang Y","Chen Y","Su Z","Zheng G","Zhang B","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1.","description":"<h4>Background</h4>Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.<h4>Objective</h4>This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.<h4>Methods</h4>We analyzed microarray data (GSE41662) to investigate the gene expression of <i>SKP2</i> in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-05-22T03:13:41.891Z","creation":"2025-04-06T22:17:08.45Z"},"accession":"S-EPMC11439983","cross_references":{"pubmed":["39343755"],"doi":["10.5021/ad.23.118"]}}