biostudies-literatureTang LGuangdong Provincial Hospital of Chinese MedicineThe 2020 Guangdong Provincial Science and Technology Innovation Strategy Special FundAdministration of Traditional Chinese Medicine of Guangdong ProvinceSpecific Fund of State Key Laboratory of Dampness Syndrome of Chinese MedicineNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong ProvinceGuangdong College of Traditional Chinese Medicine282-291https://www.ebi.ac.uk/biostudies/studies/S-EPMC11439983biostudies-literatureUnknown36(5)<h4>Background</h4>Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.<h4>Objective</h4>This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.<h4>Methods</h4>We analyzed microarray data (GSE41662) to investigate the gene expression of <i>SKP2</i> in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-Annals of dermatologyUpregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1.PMC11439983YN2024HL04SZ2021ZZ23YN2018QJ03820043772020B12120300062024A151503014820222066SZ2022QN10Li GLiu HZheng XLi CZhu YHuang HHan WLi QWu DFeng BLiu TDai ZWang MTang LQiu XZhang ZZhang YChen YSu ZZheng GZhang BZhao JfalseUpregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1.<h4>Background</h4>Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.<h4>Objective</h4>This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.<h4>Methods</h4>We analyzed microarray data (GSE41662) to investigate the gene expression of <i>SKP2</i> in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-2024-01-01T00:00:00Z2024 Oct2026-05-22T03:13:41.891Z2025-04-06T22:17:08.45ZS-EPMC114399833934375510.5021/ad.23.118