biostudies-literatureKao YTNational Science and Technology CouncilLinkou Chang Gung Memorial Hospital1485https://www.ebi.ac.uk/biostudies/studies/S-EPMC11440110biostudies-literatureUnknown16(9)<h4>Background</h4>Hepatocellular carcinoma (HCC) remains a significant concern for patients with chronic hepatitis C (HCV), even after achieving a sustained virological response (SVR) with direct-acting antivirals (DAAs) or interferon (IFN)-based therapies. This study compared the risk of HCC in patients with HCV who achieved SVR through the DAA versus IFN regimens.<h4>Methods</h4>A retrospective analysis was conducted on 4806 HCV patients, without coinfection nor prior HCC history, treated at the Chang Gung Memorial Hospital, Taiwan (DAA: 2825, IFN: 1981). Kaplan-Meier and Cox regression analyses with propensity score matching (PSM) were used to adjust for baseline differences.<h4>Results</h4>DAA-treated patients exhibited a higher incidence of HCC than IFN-treated patients before and afVirusesHepatocellular Carcinoma Incidences and Risk Factors in Hepatitis C Patients: Interferon versus Direct-Acting Agents.PMC11440110CMRPG3N0851NMRPG3P6021Tai JCHsieh YCKao YTChen YCWen YWChien RNCheng YTLin CYSu CWSheen ISTai DIJeng WJLiu YCHsu CEfalseHepatocellular Carcinoma Incidences and Risk Factors in Hepatitis C Patients: Interferon versus Direct-Acting Agents.<h4>Background</h4>Hepatocellular carcinoma (HCC) remains a significant concern for patients with chronic hepatitis C (HCV), even after achieving a sustained virological response (SVR) with direct-acting antivirals (DAAs) or interferon (IFN)-based therapies. This study compared the risk of HCC in patients with HCV who achieved SVR through the DAA versus IFN regimens.<h4>Methods</h4>A retrospective analysis was conducted on 4806 HCV patients, without coinfection nor prior HCC history, treated at the Chang Gung Memorial Hospital, Taiwan (DAA: 2825, IFN: 1981). Kaplan-Meier and Cox regression analyses with propensity score matching (PSM) were used to adjust for baseline differences.<h4>Results</h4>DAA-treated patients exhibited a higher incidence of HCC than IFN-treated patients before and af2024-01-01T00:00:00Z2024 Sep2025-04-04T02:20:01.564Z2025-04-04T02:20:01.564ZS-EPMC114401103933996110.3390/v16091485