{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Anaguano D"],"funding":["National Institute of Allergy and Infectious Diseases","Graduate School, University of Georgia","Johns Hopkins Malaria Research Institute","NIAID NIH HHS","The Daniel G. Colley Training in Parasitology Fund, Center for Tropical & Emerging Global Diseases, University of Georgia","National Institutes of Health","Bloomberg Philanthropies"],"pagination":["e3002801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11441699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(9)"],"pubmed_abstract":["Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium. Parasite proliferation within human red blood cells (RBCs) is associated with the clinical manifestations of the disease. This asexual expansion within human RBCs begins with the invasion of RBCs by P. falciparum, which is mediated by the secretion of effectors from 2 specialized club-shaped secretory organelles in merozoite-stage parasites known as rhoptries. We investigated the function of the Rhoptry Neck Protein 11 (RON11), which contains 7 transmembrane domains and calcium-binding EF-hand domains. We generated conditional mutants of the P. falciparum RON11. Knockdown of RON11 inhibits parasite growth by preventing merozoite invasion. The loss of RON11 did not lead to any defects "],"journal":["PLoS biology"],"pubmed_title":["Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion."],"pmcid":["PMC11441699"],"funding_grant_id":["R56 AI173133","AI173133","T32 AI060546","T32 AI138953"],"pubmed_authors":["Blauwkamp J","Absalon S","Anaguano D","Adewale-Fasoro O","Srinivasan P","Yanik S","Muralidharan V","Vick GW","Fierro MA"],"additional_accession":[]},"is_claimable":false,"name":"Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion.","description":"Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium. Parasite proliferation within human red blood cells (RBCs) is associated with the clinical manifestations of the disease. This asexual expansion within human RBCs begins with the invasion of RBCs by P. falciparum, which is mediated by the secretion of effectors from 2 specialized club-shaped secretory organelles in merozoite-stage parasites known as rhoptries. We investigated the function of the Rhoptry Neck Protein 11 (RON11), which contains 7 transmembrane domains and calcium-binding EF-hand domains. We generated conditional mutants of the P. falciparum RON11. Knockdown of RON11 inhibits parasite growth by preventing merozoite invasion. The loss of RON11 did not lead to any defects ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T01:01:23.97Z","creation":"2025-04-04T01:01:23.97Z"},"accession":"S-EPMC11441699","cross_references":{"pubmed":["39292724"],"doi":["10.1371/journal.pbio.3002801"]}}