{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hubscher T"],"funding":["École Polytechnique Fédérale de Lausanne","Wellcome Trust"],"pagination":["dev202853"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11441983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(17)"],"pubmed_abstract":["Although the advent of organoids has opened unprecedented perspectives for basic and translational research, immune system-related organoids remain largely underdeveloped. Here, we established organoids from the thymus, the lymphoid organ responsible for T-cell development. We identified conditions enabling mouse thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles resembling in vivo thymic epithelial cells (TECs) more closely than traditional TEC cultures. In contrast to these two-dimensional cultures, thymic epithelial organoids maintained thymus functionality in vitro and mediated physiological T-cell development upon reaggregation with T-cell progenitors. The reaggregates showed in vivo-like epithelial"],"journal":["Development (Cambridge, England)"],"pubmed_title":["Thymic epithelial organoids mediate T-cell development."],"pmcid":["PMC11441983"],"funding_grant_id":["211944/Z/18/Z"],"pubmed_authors":["Blackburn CC","Tillard L","Langer JJ","Hubscher T","Rouse P","Lorenzo-Martin LF","Lutolf MP","Hollander G","Barthlott T"],"additional_accession":[]},"is_claimable":false,"name":"Thymic epithelial organoids mediate T-cell development.","description":"Although the advent of organoids has opened unprecedented perspectives for basic and translational research, immune system-related organoids remain largely underdeveloped. Here, we established organoids from the thymus, the lymphoid organ responsible for T-cell development. We identified conditions enabling mouse thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles resembling in vivo thymic epithelial cells (TECs) more closely than traditional TEC cultures. In contrast to these two-dimensional cultures, thymic epithelial organoids maintained thymus functionality in vitro and mediated physiological T-cell development upon reaggregation with T-cell progenitors. The reaggregates showed in vivo-like epithelial","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-02T18:41:51.319Z","creation":"2025-04-04T11:03:57.061Z"},"accession":"S-EPMC11441983","cross_references":{"pubmed":["39036995"],"doi":["10.1242/dev.202853"]}}