{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kappel D"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11442302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(1)"],"pubmed_abstract":["<i>Candida auris</i> is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant <i>C. auris</i> within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of <i>C. auris</i> introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission event"],"journal":["npj antimicrobials and resistance"],"pubmed_title":["Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant &lt;i&gt;Candida auris&lt;/i&gt;."],"pmcid":["PMC11442302"],"funding_grant_id":["219551/Z/19/Z","MR/R015600/1"],"pubmed_authors":["Rhodes J","Borman A","Brown CS","Fisher MC","Schlenz S","Kappel D","Abdolrasouli A","Eyre DW","Jeffery K","Brackin A","Aanensen DM","Holmes A","Gifford H","Armstrong-James D","Johnson E"],"additional_accession":[]},"is_claimable":false,"name":"Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant &lt;i&gt;Candida auris&lt;/i&gt;.","description":"<i>Candida auris</i> is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant <i>C. auris</i> within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of <i>C. auris</i> introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission event","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-15T04:09:25.336Z","creation":"2025-04-04T01:54:47.146Z"},"accession":"S-EPMC11442302","cross_references":{"pubmed":["39359891"],"doi":["10.1038/s44259-024-00043-6"]}}