biostudies-literatureKappel DMedical Research CouncilWellcome Trust26https://www.ebi.ac.uk/biostudies/studies/S-EPMC11442302biostudies-literatureUnknown2(1)<i>Candida auris</i> is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant <i>C. auris</i> within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of <i>C. auris</i> introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission eventnpj antimicrobials and resistanceGenomic epidemiology describes introduction and outbreaks of antifungal drug-resistant &lt;i&gt;Candida auris&lt;/i&gt;.PMC11442302219551/Z/19/ZMR/R015600/1Rhodes JBorman ABrown CSFisher MCSchlenz SKappel DAbdolrasouli AEyre DWJeffery KBrackin AAanensen DMHolmes AGifford HArmstrong-James DJohnson EfalseGenomic epidemiology describes introduction and outbreaks of antifungal drug-resistant &lt;i&gt;Candida auris&lt;/i&gt;.<i>Candida auris</i> is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant <i>C. auris</i> within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of <i>C. auris</i> introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission event2024-01-01T00:00:00Z20242026-07-15T04:09:25.336Z2025-04-04T01:54:47.146ZS-EPMC114423023935989110.1038/s44259-024-00043-6