{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang D"],"funding":["Natural Science Foundation of Fujian Province","National Natural Science Foundation of China","The Joint Funds for the Innovation of Science and Technology"],"pagination":["e70065"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11442333"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(10)"],"pubmed_abstract":["<h4>Aims</h4>Previous proteomics studies in dysferlinopathy muscle have been limited in scope, often utilizing 2D-electrophoresis and yielding only a small number of differential expression calls. To address this gap, this study aimed to employ high-resolution proteomics to explore the proteomic landscapes of dysferlinopathy and analyze the correlation between muscle pathological changes and alterations in protein expression in muscle biopsies.<h4>Methods</h4>We conducted a comprehensive approach to investigate the proteomic profile and disease-associated changes in the muscle tissue proteome from 15 patients with dysferlinopathy, exhibiting varying degrees of dystrophic pathology, alongside age-matched controls. Our methodology encompasses tandem mass tag (TMT)-labeled liquid chromatograp"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Comprehensive Proteomic Analysis of Dysferlinopathy Unveiling Molecular Mechanisms and Biomarkers Linked to Pathological Progression."],"pmcid":["PMC11442333"],"funding_grant_id":["2020Y9122","82101471","81701242","2023J01620"],"pubmed_authors":["Zheng Y","Liu XY","Wang D","Chen L","Lin X","Zheng FZ","Zeng MH","Wang N","Lin YH","Wang ZQ","Lin F","Lin MT","He QF","Chen HZ"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Proteomic Analysis of Dysferlinopathy Unveiling Molecular Mechanisms and Biomarkers Linked to Pathological Progression.","description":"<h4>Aims</h4>Previous proteomics studies in dysferlinopathy muscle have been limited in scope, often utilizing 2D-electrophoresis and yielding only a small number of differential expression calls. To address this gap, this study aimed to employ high-resolution proteomics to explore the proteomic landscapes of dysferlinopathy and analyze the correlation between muscle pathological changes and alterations in protein expression in muscle biopsies.<h4>Methods</h4>We conducted a comprehensive approach to investigate the proteomic profile and disease-associated changes in the muscle tissue proteome from 15 patients with dysferlinopathy, exhibiting varying degrees of dystrophic pathology, alongside age-matched controls. Our methodology encompasses tandem mass tag (TMT)-labeled liquid chromatograp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T05:36:15.885Z","creation":"2025-04-04T19:39:31.992Z"},"accession":"S-EPMC11442333","cross_references":{"pubmed":["39350328"],"doi":["10.1111/cns.70065"]}}