{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11442948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Stress can lead to gut dysbiosis in brain-gut axis disordered diseases as irritable bowel syndrome (IBS), yet the mechanisms how stress transfer from the brain to the gut and disrupt gut microbiota remain elusive. Here we describe a stress-responsive brain-to-gut axis which impairs colonocytes' mitochondria to trigger gut dysbiosis. Patients with IBS exhibit significantly increased facultative anaerobes and decreased obligate anaerobes, related to increased serum corticotropin-releasing hormone (CRH) level and defected colonocytes' mitochondria ultrastructure. Mice exposed to acute stress experienced enhanced CRH-CRH receptor type 1 (CRHR1) signaling, which impaired mitochondria and epithelium hypoxia in the colon, subsequently triggered gut dysbiosis. Antagonizing CRHR1 expression to inhi"],"journal":["NPJ biofilms and microbiomes"],"pubmed_title":["Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway."],"pmcid":["PMC11442948"],"funding_grant_id":["82470578","82170557"],"pubmed_authors":["Li X","Duan L","Zheng H","Zhang Z","Zhang J","Zhang Y","Guo H","Lu S","Zhang C","Pei F","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway.","description":"Stress can lead to gut dysbiosis in brain-gut axis disordered diseases as irritable bowel syndrome (IBS), yet the mechanisms how stress transfer from the brain to the gut and disrupt gut microbiota remain elusive. Here we describe a stress-responsive brain-to-gut axis which impairs colonocytes' mitochondria to trigger gut dysbiosis. Patients with IBS exhibit significantly increased facultative anaerobes and decreased obligate anaerobes, related to increased serum corticotropin-releasing hormone (CRH) level and defected colonocytes' mitochondria ultrastructure. Mice exposed to acute stress experienced enhanced CRH-CRH receptor type 1 (CRHR1) signaling, which impaired mitochondria and epithelium hypoxia in the colon, subsequently triggered gut dysbiosis. Antagonizing CRHR1 expression to inhi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-06T22:20:45.586Z","creation":"2025-04-04T23:43:05.247Z"},"accession":"S-EPMC11442948","cross_references":{"pubmed":["39349483"],"doi":["10.1038/s41522-024-00571-z"]}}