{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dou H"],"funding":["NHLBI NIH HHS","NCI NIH HHS"],"pagination":["1758-1772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11443577"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(17)"],"pubmed_abstract":["<h4>Abstract</h4>Increased eosinophil counts are associated with cardiovascular disease and may be an independent predictor of major cardiovascular events. However, the causality and underlying mechanisms are poorly understood. Genome-wide association studies have shown an association of a common LNK variant (R262W, T allele) with eosinophilia and atherothrombotic disorders. LNK(TT) reduces LNK function, and Lnk-deficient mice display accelerated atherosclerosis and thrombosis. This study was undertaken to assess the role of eosinophils in arterial thrombosis in mice with hematopoietic Lnk deficiency. Hematopoietic Lnk deficiency increased circulating and activated eosinophils, JAK/STAT signaling in eosinophils, and carotid arterial thrombosis with increased eosinophil abundance and extrac"],"journal":["Blood"],"pubmed_title":["Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis."],"pmcid":["PMC11443577"],"funding_grant_id":["R01 HL148071","R01 HL118567","R01 CA225231","R01 CA271418","R01 HL137663","R01 HL155431","R01 CA271331","R01 CA260711"],"pubmed_authors":["Dou H","Tall AR","Wang N","Tavallaie M","Wang R","Olszewska M","Papapetrou EP","Xiao T"],"additional_accession":[]},"is_claimable":false,"name":"Hematopoietic and eosinophil-specific LNK(SH2B3) deficiency promotes eosinophilia and arterial thrombosis.","description":"<h4>Abstract</h4>Increased eosinophil counts are associated with cardiovascular disease and may be an independent predictor of major cardiovascular events. However, the causality and underlying mechanisms are poorly understood. Genome-wide association studies have shown an association of a common LNK variant (R262W, T allele) with eosinophilia and atherothrombotic disorders. LNK(TT) reduces LNK function, and Lnk-deficient mice display accelerated atherosclerosis and thrombosis. This study was undertaken to assess the role of eosinophils in arterial thrombosis in mice with hematopoietic Lnk deficiency. Hematopoietic Lnk deficiency increased circulating and activated eosinophils, JAK/STAT signaling in eosinophils, and carotid arterial thrombosis with increased eosinophil abundance and extrac","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T12:02:21.578Z","creation":"2026-04-18T03:11:05.934Z"},"accession":"S-EPMC11443577","cross_references":{"pubmed":["38096361"],"doi":["10.1182/blood.2023021055"]}}