{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Trasande L"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Institutes of Health","NIH HHS","Office of Behavioral and Social Sciences Research"],"pagination":["e74-e85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11444077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["<h4>Background</h4>Phthalates are synthetic chemicals widely used in consumer products and have been identified to contribute to preterm birth. Existing studies have methodological limitations and potential effects of di-2-ethylhexyl phthalate (DEHP) replacements are poorly characterised. Attributable fractions and costs have not been quantified, limiting the ability to weigh trade-offs involved in ongoing use. We aimed to leverage a large, diverse US cohort to study associations of phthalate metabolites with birthweight and gestational age, and estimate attributable adverse birth outcomes and associated costs.<h4>Methods</h4>In this prospective analysis we used extant data in the US National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) Program from 1998 to"],"journal":["The Lancet. Planetary health"],"pubmed_title":["Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs."],"pmcid":["PMC11444077"],"funding_grant_id":["UH3OD023318","UH3OD023251","U24 OD023319","UH3OD023272","UH3 OD023290","UH3OD023271","UG3 OD023251","UH3 OD023251","P30 ES017885","UH3OD023290","UH3 OD023272","UH3 OD023271","U24OD023382","U2C OD023375","UH3 OD023318","U24 OD023382","UH3OD023305","UG3 OD023305","UH3OD023248","U24OD023319","P2C ES033423","P30 ES010126","UH3OD023342","P2CES033423","UH3OD023285","U2COD023375","UH3 OD023285","UH3 OD023342","UH3 OD023248","UH3 OD023305"],"pubmed_authors":["Newschaffer C","Catellier DJ","Nelson ME","Smith PB","Elliott M","Starling AP","Volk H","Dabelea D","Kerver JM","Newby KL","Barone C","Schmidt R","Naidu M","Zhao Q","Gershon R","Romano ME","Karr C","Ruden DM","Schantz SL","Lyall K","Dunlop AL","Tylavsky F","Nguyen R","Jacobson LP","Sathyanarayana S","programme collaborators for Environmental influences on Child Health Outcomes","Bush N","Mason A","Barrett ES","Meeker JD","Alshawabkeh A","Cordero J","Buckley JP","Herbstman JB","LeWinn KZ","Swan S","Fussman C","Padula AM","Hamra GB","Cella D","Trasande L","Paneth N"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs.","description":"<h4>Background</h4>Phthalates are synthetic chemicals widely used in consumer products and have been identified to contribute to preterm birth. Existing studies have methodological limitations and potential effects of di-2-ethylhexyl phthalate (DEHP) replacements are poorly characterised. Attributable fractions and costs have not been quantified, limiting the ability to weigh trade-offs involved in ongoing use. We aimed to leverage a large, diverse US cohort to study associations of phthalate metabolites with birthweight and gestational age, and estimate attributable adverse birth outcomes and associated costs.<h4>Methods</h4>In this prospective analysis we used extant data in the US National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) Program from 1998 to","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-06T22:23:40.373Z","creation":"2025-04-03T23:48:50.969Z"},"accession":"S-EPMC11444077","cross_references":{"pubmed":["38331533"],"doi":["10.1016/S2542-5196(23)00270-X"]}}